气候变化领域集成服务门户(CCPortal): Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions

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DOI	10.1073/pnas.2013972118
	Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions
	Brancati G.E.; Rawas C.; Ghestem A.; Bernard C.; Ivanov A.I.
发表日期	2021
ISSN	00278424
卷号	118 期号:11
英文摘要	The hippocampus's dorsal and ventral parts are involved in different operative circuits, the functions of which vary in time during the night and day cycle. These functions are altered in epilepsy. Since energy production is tailored to function, we hypothesized that energy production would be space- and time-dependent in the hippocampus and that such an organizing principle would be modified in epilepsy. Using metabolic imaging and metabolite sensing ex vivo, we show that the ventral hippocampus favors aerobic glycolysis over oxidative phosphorylation as compared to the dorsal part in the morning in control mice. In the afternoon, aerobic glycolysis is decreased and oxidative phosphorylation increased. In the dorsal hippocampus, the metabolic activity varies less between these two times but is weaker than in the ventral. Thus, the energy metabolism is different along the dorsoventral axis and changes as a function of time in control mice. In an experimental model of epilepsy, we find a large alteration of such spatiotemporal organization. In addition to a general hypometabolic state, the dorsoventral difference disappears in the morning, when seizure probability is low. In the afternoon, when seizure probability is high, the aerobic glycolysis is enhanced in both parts, the increase being stronger in the ventral area. We suggest that energy metabolism is tailored to the functions performed by brain networks, which vary over time. In pathological conditions, the alterations of these general rules may contribute to network dysfunctions. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Aerobic glycolysis; Circadian regulation; Energy metabolism; Hippocampus; Temporal lobe epilepsy
语种	英语
scopus关键词	adult; aerobic glycolysis; animal experiment; animal model; animal tissue; Article; cognitive defect; controlled study; dorsal hippocampus; energy metabolism; energy yield; epilepsy; ex vivo study; experimental epilepsy; hippocampus; human; male; mouse; nonhuman; oxidative phosphorylation; priority journal; seizure; spatiotemporal analysis; temporal lobe epilepsy; ventral hippocampus
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180255
作者单位	Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 56126, Italy
推荐引用方式 GB/T 7714	Brancati G.E.,Rawas C.,Ghestem A.,et al. Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions[J],2021,118(11).
APA	Brancati G.E.,Rawas C.,Ghestem A.,Bernard C.,&Ivanov A.I..(2021).Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions.Proceedings of the National Academy of Sciences of the United States of America,118(11).
MLA	Brancati G.E.,et al."Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions".Proceedings of the National Academy of Sciences of the United States of America 118.11(2021).