气候变化领域集成服务门户(CCPortal): Antigenic cartography reveals complexities of genetic determinants that lead to antigenic differences among pandemic GII.4 noroviruses

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DOI	10.1073/pnas.2015874118
	Antigenic cartography reveals complexities of genetic determinants that lead to antigenic differences among pandemic GII.4 noroviruses
	Kendra J.A.; Tohma K.; Lauren A. Ford-Siltz; Lepore C.J.; Parra G.I.
发表日期	2021
ISSN	00278424
卷号	118 期号:11
英文摘要	Noroviruses are the predominant cause of acute gastroenteritis, with a single genotype (GII.4) responsible for the majority of infections. This prevalence is characterized by the periodic emergence of new variants that present substitutions at antigenic sites of the major structural protein (VP1), facilitating escape from herd immunity. Notably, the contribution of intravariant mutations to changes in antigenic properties is unknown. We performed a comprehensive antigenic analysis on a virus-like particle panel representing major chronological GII.4 variants to investigate diversification at the inter- and intravariant level. Immunoassays, neutralization data, and cartography analyses showed antigenic similarities between phylogenetically related variants, with major switches to antigenic properties observed over the evolution of GII.4 variants. Genetic analysis indicated that multiple coevolving amino acid changes-primarily at antigenic sites-are associated with the antigenic diversification of GII.4 variants. These data highlight complexities of the genetic determinants and provide a framework for the antigenic characterization of emerging GII.4 noroviruses. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Antigenic cartography; Antigenic mapping; GII.4 noroviruses; Norovirus; Pandemic
语种	英语
scopus关键词	amino acid; structural protein; acute gastroenteritis; antigenicity; Article; Caliciviridae; controlled study; cross reaction; environment; epithelium cell; gene mutation; genetic analysis; genotype; herd immunity; immunoassay; nonhuman; Norovirus; norovirus infection; open reading frame; pandemic; phylogeny; prevalence; priority journal; virus neutralization; virus replication
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180239
作者单位	Division of Viral Products, Food and Drug Administration, Silver Spring, MD 20993, United States
推荐引用方式 GB/T 7714	Kendra J.A.,Tohma K.,Lauren A. Ford-Siltz,et al. Antigenic cartography reveals complexities of genetic determinants that lead to antigenic differences among pandemic GII.4 noroviruses[J],2021,118(11).
APA	Kendra J.A.,Tohma K.,Lauren A. Ford-Siltz,Lepore C.J.,&Parra G.I..(2021).Antigenic cartography reveals complexities of genetic determinants that lead to antigenic differences among pandemic GII.4 noroviruses.Proceedings of the National Academy of Sciences of the United States of America,118(11).
MLA	Kendra J.A.,et al."Antigenic cartography reveals complexities of genetic determinants that lead to antigenic differences among pandemic GII.4 noroviruses".Proceedings of the National Academy of Sciences of the United States of America 118.11(2021).