气候变化领域集成服务门户(CCPortal): A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defenses

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DOI	10.1073/PNAS.2100825118
	A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defenses
	Chen D.; Roychowdhury-Sinha A.; Prakash P.; Lan X.; Fan W.; Goto A.; Hoffmann J.A.
发表日期	2021
ISSN	00278424
卷号	118 期号:12
英文摘要	Oncogenic RasV12 cells [A. Simcox et al., PLoS Genet. 4, e1000142 (2008)] injected into adult males proliferated massively after a lag period of several days, and led to the demise of the flies after 2 to 3 wk. The injection induced an early massive transcriptomic response that, unexpectedly, included more than 100 genes encoding chemoreceptors of various families. The kinetics of induction and the identities of the induced genes differed markedly from the responses generated by injections of microbes. Subsequently, hundreds of genes were up-regulated, attesting to intense catabolic activities in the flies, active tracheogenesis, and cuticulogenesis, as well as stress and inflammation-type responses. At 11 d after the injections, GFP-positive oncogenic cells isolated from the host flies exhibited a markedly different transcriptomic profile from that of the host and distinct from that at the time of their injection, including in particular up-regulated expression of genes typical for cells engaged in the classical antimicrobial response of Drosophila. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cancer; Chemoreceptor; Drosophila melanogaster; Innate immunity; RasV12
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180209
作者单位	Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, 511436, China; Insect Models of Innate Immunity (M3I; UPR9022), CNRS, University of Strasbourg, Strasbourg, F-67084, France; University of Strasbourg, Institute for Advanced Study, Strasbourg, 67000, France
推荐引用方式 GB/T 7714	Chen D.,Roychowdhury-Sinha A.,Prakash P.,et al. A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defenses[J],2021,118(12).
APA	Chen D..,Roychowdhury-Sinha A..,Prakash P..,Lan X..,Fan W..,...&Hoffmann J.A..(2021).A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defenses.Proceedings of the National Academy of Sciences of the United States of America,118(12).
MLA	Chen D.,et al."A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defenses".Proceedings of the National Academy of Sciences of the United States of America 118.12(2021).