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DOI | 10.1073/PNAS.2021758118 |
Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury | |
Tanaka S.; Abe C.; Abbott S.B.G.; Zheng S.; Yamaoka Y.; Lipsey J.E.; Skrypnyk N.I.; Yao J.; Inoue T.; Nash W.T.; Stornetta D.S.; Rosin D.L.; Stornetta R.L.; Guyenet P.G.; Okusa M.D. | |
发表日期 | 2021 |
ISSN | 00278424 |
卷号 | 118期号:12 |
英文摘要 | Acute kidney injury is highly prevalent and associated with high morbidity and mortality, and there are no approved drugs for its prevention and treatment. Vagus nerve stimulation (VNS) alleviates inflammatory diseases including kidney disease; however, neural circuits involved in VNS-induced tissue protection remain poorly understood. The vagus nerve, a heterogeneous group of neural fibers, innervates numerous organs. VNS broadly stimulates these fibers without specificity. We used optogenetics to selectively stimulate vagus efferent or afferent fibers. Anterograde efferent fiber stimulation or anterograde (centripetal) sensory afferent fiber stimulation both conferred kidney protection from ischemia-reperfusion injury. We identified the C1 neurons-sympathetic nervous system-splenic nerve-spleen-kidney axis as the downstream pathway of vagus afferent fiber stimulation. Our study provides a map of the neural circuits important for kidney protection induced by VNS, which is critical for the safe and effective clinical application of VNS for protection from acute kidney injury. © 2021 National Academy of Sciences. All rights reserved. |
英文关键词 | Acute kidney injury; Neuroimmune interactions; Sympathetic nervous system; Vagus nerve stimulation |
语种 | 英语 |
scopus关键词 | adrenergic system; animal experiment; animal tissue; Article; clinical effectiveness; controlled study; efferent nerve; kidney injury; male; mouse; nerve cell; nerve potential; neuroimmunology; nonhuman; optogenetics; priority journal; renal ischemia reperfusion injury; renal protection; safety; sensory nerve; spleen; vagus nerve stimulation |
来源期刊 | Proceedings of the National Academy of Sciences of the United States of America
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文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/180205 |
作者单位 | Division of Nephrology, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, United States; Department of Physiology, Gifu University, Graduate School of Medicine, Gifu, 501-1194, Japan; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, United States; Division of Chronic Kidney Disease Pathophysiology, University of Tokyo, Graduate School of Medicine, Tokyo, 113-0033, Japan |
推荐引用方式 GB/T 7714 | Tanaka S.,Abe C.,Abbott S.B.G.,et al. Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury[J],2021,118(12). |
APA | Tanaka S..,Abe C..,Abbott S.B.G..,Zheng S..,Yamaoka Y..,...&Okusa M.D..(2021).Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury.Proceedings of the National Academy of Sciences of the United States of America,118(12). |
MLA | Tanaka S.,et al."Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury".Proceedings of the National Academy of Sciences of the United States of America 118.12(2021). |
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