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DOI	10.1073/pnas.2023613118
	The synaptonemal complex imposes crossover interference and heterochiasmy in Arabidopsis
	Capilla-Pérez L.; Durand S.; Hurel A.; Lian Q.; Chambon A.; Taochy C.; Solier V.; Grelon M.; Mercier R.
发表日期	2021
ISSN	00278424
卷号	118 期号:12
英文摘要	Meiotic crossovers (COs) have intriguing patterning properties, including CO interference, the tendency of COs to be well-spaced along chromosomes, and heterochiasmy, the marked difference in male and female CO rates. During meiosis, transverse filaments transiently associate the axes of homologous chromosomes, a process called synapsis that is essential for CO formation in many eukaryotes. Here, we describe the spatial organization of the transverse filaments in Arabidopsis (ZYP1) and show it to be evolutionary conserved. We show that in the absence of ZYP1 (zyp1a zyp1b null mutants), chromosomes associate in pairs but do not synapse. Unexpectedly, in absence of ZYP1, CO formation is not prevented but increased. Furthermore, genome-wide analysis of recombination revealed that CO interference is abolished, with the frequent observation of close COs. In addition, heterochiasmy was erased, with identical CO rates in males and females. This shows that the tripartite synaptonemal complex is dispensable for CO formation and has a key role in regulating their number and distribution, imposing CO interference and heterochiasmy. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Crossover \| interference \| heterochiasmy \| synaptonemal complex \| meiosis
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180187
作者单位	Department of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, 50829, Germany; Institut Jean-Pierre Bourgin, INRAE, AgroParisTech, Université Paris-Saclay, Versailles, 78000, France
推荐引用方式 GB/T 7714	Capilla-Pérez L.,Durand S.,Hurel A.,et al. The synaptonemal complex imposes crossover interference and heterochiasmy in Arabidopsis[J],2021,118(12).
APA	Capilla-Pérez L..,Durand S..,Hurel A..,Lian Q..,Chambon A..,...&Mercier R..(2021).The synaptonemal complex imposes crossover interference and heterochiasmy in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America,118(12).
MLA	Capilla-Pérez L.,et al."The synaptonemal complex imposes crossover interference and heterochiasmy in Arabidopsis".Proceedings of the National Academy of Sciences of the United States of America 118.12(2021).