气候变化领域集成服务门户(CCPortal): Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers

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DOI	10.1073/pnas.2018459118
	Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers
	Sukenik N.; Vinogradov O.; Weinreb E.; Segal M.; Levina A.; Moses E.
发表日期	2021
ISSN	00278424
卷号	118 期号:12
英文摘要	The interplay between excitation and inhibition is crucial for neuronal circuitry in the brain. Inhibitory cell fractions in the neocortex and hippocampus are typically maintained at 15 to 30%, which is assumed to be important for stable dynamics. We have studied systematically the role of precisely controlled excitatory/inhibitory (E/I) cellular ratios on network activity using mice hippocampal cultures. Surprisingly, networks with varying E/I ratios maintain stable bursting dynamics. Interburst intervals remain constant for most ratios, except in the extremes of 0 to 10% and 90 to 100% inhibitory cells. Single-cell recordings and modeling suggest that networks adapt to chronic alterations of E/I compositions by balancing E/I connectivity. Gradual blockade of inhibition substantiates the agreement between the model and experiment and defines its limits. Combining measurements of population and single-cell activity with theoretical modeling, we provide a clearer picture of how E/I balance is preserved and where it fails in living neuronal networks. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	E/I balance \| neuronal network \| network dynamics \| bursting
语种	英语
scopus关键词	animal experiment; article; cell activity; controlled study; excitation; hippocampus; male; mouse; nerve cell network; nonhuman
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180186
作者单位	Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, 7610001, Israel; Department of Computer Science, University of Tübingen, Tübingen, 72076, Germany; Graduate Training Centre of Neuroscience, University of Tübingen, Tübingen, 72074, Germany; Max Planck Institute for Biological Cybernetics, Tübingen, 72076, Germany; Department of Neurobiology, Weizmann Institute of Science, Rehovot, 7610001, Israel
推荐引用方式 GB/T 7714	Sukenik N.,Vinogradov O.,Weinreb E.,et al. Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers[J],2021,118(12).
APA	Sukenik N.,Vinogradov O.,Weinreb E.,Segal M.,Levina A.,&Moses E..(2021).Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers.Proceedings of the National Academy of Sciences of the United States of America,118(12).
MLA	Sukenik N.,et al."Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers".Proceedings of the National Academy of Sciences of the United States of America 118.12(2021).