气候变化领域集成服务门户(CCPortal): High-salt diet suppresses autoimmune demyelination by regulating the blood

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DOI	10.1073/pnas.2025944118
	High-salt diet suppresses autoimmune demyelination by regulating the blood–brain barrier permeability
	Na S.-Y.; Janakiraman M.; Leliavski A.; Krishnamoorthy G.
发表日期	2021
ISSN	00278424
卷号	118 期号:12
英文摘要	Sodium chloride, “salt,” is an essential component of daily food and vitally contributes to the body’s homeostasis. However, excessive salt intake has often been held responsible for numerous health risks associated with the cardiovascular system and kidney. Recent reports linked a high-salt diet (HSD) to the exacerbation of artificially induced central nervous system (CNS) autoimmune pathology through changes in microbiota and enhanced TH17 cell differentiation [M. Kleinewietfeld et al., Nature 496, 518–522 (2013); C. Wu et al., Nature 496, 513–517 (2013); N. Wilck et al., Nature 551, 585–589 (2017)]. However, there is no evidence that dietary salt promotes or worsens a spontaneous autoimmune disease. Here we show that HSD suppresses autoimmune disease development in a mouse model of spontaneous CNS autoimmunity. We found that HSD consumption increased the circulating serum levels of the glucocorticoid hormone corticosterone. Corticosterone enhanced the expression of tight junction molecules on the brain endothelial cells and promoted the tightening of the blood–brain barrier (BBB) thereby controlling the entry of inflammatory T cells into the CNS. Our results demonstrate the multifaceted and potentially beneficial effects of moderately increased salt consumption in CNS autoimmunity. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Multiple sclerosis \| dietary salt \| experimental autoimmune encephalomyelitis
语种	英语
scopus关键词	corticosterone; animal cell; animal experiment; animal model; animal tissue; Article; autoimmunity; blood brain barrier; cell infiltration; controlled study; corticosterone blood level; demyelination; endothelium cell; experimental autoimmune encephalomyelitis; high salt diet; inflammation; mouse; multiple sclerosis; neuroprotection; nonhuman; priority journal; T lymphocyte; tight junction
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180184
作者单位	Research Group Neuroinflammation and Mucosal Immunology, Max Planck Institute of Biochemistry, Martinsried, 82152, Germany
推荐引用方式 GB/T 7714	Na S.-Y.,Janakiraman M.,Leliavski A.,等. High-salt diet suppresses autoimmune demyelination by regulating the blood–brain barrier permeability[J],2021,118(12).
APA	Na S.-Y.,Janakiraman M.,Leliavski A.,&Krishnamoorthy G..(2021).High-salt diet suppresses autoimmune demyelination by regulating the blood–brain barrier permeability.Proceedings of the National Academy of Sciences of the United States of America,118(12).
MLA	Na S.-Y.,et al."High-salt diet suppresses autoimmune demyelination by regulating the blood–brain barrier permeability".Proceedings of the National Academy of Sciences of the United States of America 118.12(2021).