气候变化领域集成服务门户(CCPortal): Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA (nc886)

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DOI	10.1073/pnas.2026580118
	Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA (nc886)
	Carpenter B.L.; Remba T.K.; Thomas S.L.; Madaj Z.; Brink L.; Tiedemann R.L.; Odendaal H.J.; Jones P.A.
发表日期	2021
ISSN	00278424
卷号	118 期号:12
英文摘要	Genomic imprinting occurs before fertilization, impacts every cell of the developing child, and may be sensitive to environmental perturbations. The noncoding RNA, nc886 (also called VTRNA2-1) is the only known example of the ∼100 human genes imprinted by DNA methylation, that shows polymorphic imprinting in the population. The nc886 gene is part of an ∼1.6-kb differentially methylated region (DMR) that is methylated in the oocyte and silenced on the maternal allele in about 75% of humans worldwide. Here, we show that the presence or absence of imprinting at the nc886 DMR in an individual is consistent across different tissues, confirming that the imprint is established before cellular differentiation and is maintained into adulthood. We investigated the relationships between the frequency of imprinting in newborns and maternal age, alcohol consumption and cigarette smoking before conception in more than 1,100 mother/child pairs from South Africa. The probability of imprinting in newborns was increased in older mothers and decreased in mothers who drank alcohol before conception. On the other hand, cigarette smoking had no apparent relationship with the frequency of imprinting. These data show an epigenetic change during oocyte maturation which is potentially subject to environmental influence. Much focus has been placed on avoiding alcohol consumption during pregnancy, but our data suggest that drinking before conception may affect the epigenome of the newborn. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Imprinting; nc886; oocyte
语种	英语
scopus关键词	untranslated RNA; adolescent; adult; alcohol consumption; Article; child; cigarette smoking; controlled study; differentially methylated region; DNA methylation; epigenetic imprinting; epigenetics; female; gene; gene structure; genome imprinting; human; human cell; maternal age; nc886 gene; oocyte; oocyte maturation; priority journal; South Africa
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180123
作者单位	Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, United States; Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Cape Town, Western Cape, 7530, South Africa
推荐引用方式 GB/T 7714	Carpenter B.L.,Remba T.K.,Thomas S.L.,et al. Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA (nc886)[J],2021,118(12).
APA	Carpenter B.L..,Remba T.K..,Thomas S.L..,Madaj Z..,Brink L..,...&Jones P.A..(2021).Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA (nc886).Proceedings of the National Academy of Sciences of the United States of America,118(12).
MLA	Carpenter B.L.,et al."Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA (nc886)".Proceedings of the National Academy of Sciences of the United States of America 118.12(2021).