气候变化领域集成服务门户(CCPortal): Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity

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DOI	10.1073/PNAS.2015855118
	Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity
	Hawash M.B.F.; Sanz-Remón J.; Grenier J.-C.; Kohn J.; Yotova V.; Johnson Z.; Lanford R.E.; Brinkworth J.F.; Barreiro L.B.
发表日期	2021
ISSN	00278424
卷号	118 期号:13
英文摘要	Despite their close genetic relatedness, apes and African and Asian monkeys (AAMs) differ in their susceptibility to severe bacterial and viral infections that are important causes of human disease. Such differences between humans and other primates are thought to be a result, at least in part, of interspecies differences in immune response to infection. However, because of the lack of comparative functional data across species, it remains unclear in what ways the immune systems of humans and other primates differ. Here, we report the whole-genome transcriptomic responses of ape species (human and chimpanzee) and AAMs (rhesus macaque and baboon) to bacterial and viral stimulation. We find stark differences in the responsiveness of these groups, with apes mounting a markedly stronger early transcriptional response to both viral and bacterial stimulation, altering the transcription of ∼40% more genes than AAMs. Additionally, we find that genes involved in the regulation of inflammatory and interferon responses show the most divergent early transcriptional responses across primates and that this divergence is attenuated over time. Finally, we find that relative to AAMs, apes engage a much less specific immune response to different classes of pathogens during the early hours of infection, up-regulating genes typical of antiviral and anti-bacterial responses regardless of the nature of the stimulus. Overall, these findings suggest apes exhibit increased sensitivity to bacterial and viral immune stimulation, activating a broader array of defense molecules that may be beneficial for early pathogen killing at the potential cost of increased energy expenditure and tissue damage. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Early immune responses to infection; Gram-negative bacteria; Immunodeficiency viruses; Pathogen-associated molecular patterns; Primate evolution
语种	英语
scopus关键词	interferon; adult; animal cell; animal experiment; Article; baboon; bacterial immunity; chimpanzee; controlled study; energy expenditure; evolutionary adaptation; female; genetic transcription; human; human cell; immunoreactivity; inflammation; innate immunity; male; nonhuman; priority journal; rhesus monkey; tissue injury; transcriptomics; upregulation; virus immunity; whole genome sequencing
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180040
作者单位	Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montréal, QC H3T 1C5, Canada; Zoology Department, Faculty of Science, Cairo University, Giza, 12613, Egypt; Departamento de Fiscia Teórica, Universidad de Zaragoza, Zaragoza, 50001, Spain; Institute for Biocomputation and Physics of Complex Systems, Universidad de Zaragoza, Zaragoza, 50018, Spain; Montreal Heart Institute, University of Montreal, Montreal, QC H1T 1C8, Canada; Department of Neuroscience, Emory University, Atlanta, GA 30329, United States; Department of Psychiatry, College of Health Sciences, University of California, San Diego, CA 92093, United States; Illumina, San Diego, CA 92122, United States; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, United States; Department of Anthropology, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States; Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, United ...
推荐引用方式 GB/T 7714	Hawash M.B.F.,Sanz-Remón J.,Grenier J.-C.,et al. Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity[J],2021,118(13).
APA	Hawash M.B.F..,Sanz-Remón J..,Grenier J.-C..,Kohn J..,Yotova V..,...&Barreiro L.B..(2021).Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity.Proceedings of the National Academy of Sciences of the United States of America,118(13).
MLA	Hawash M.B.F.,et al."Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity".Proceedings of the National Academy of Sciences of the United States of America 118.13(2021).