气候变化领域集成服务门户(CCPortal): Cortical ensembles selective for context

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DOI	10.1073/pnas.2026179118
	Cortical ensembles selective for context
	Hamm J.P.; Shymkiv Y.; Han S.; Yang W.; Yuste R.
发表日期	2021
ISSN	00278424
卷号	118 期号:14
英文摘要	Neural processing of sensory information is strongly influenced by context. For instance, cortical responses are reduced to predictable stimuli, while responses are increased to novel stimuli that deviate from contextual regularities. Such bidirectional modulation based on preceding sensory context is likely a critical component or manifestation of attention, learning, and behavior, yet how it arises in cortical circuits remains unclear. Using volumetric two-photon calcium imaging and local field potentials in primary visual cortex (V1) from awake mice presented with visual "oddball" paradigms, we identify both reductions and augmentations of stimulus-evoked responses depending, on whether the stimulus was redundant or deviant, respectively. Interestingly, deviance-augmented responses were limited to a specific subset of neurons mostly in supragranular layers. These deviance-detecting cells were spatially intermixed with other visually responsive neurons and were functionally correlated, forming a neuronal ensemble. Optogenetic suppression of prefrontal inputs to V1 reduced the contextual selectivity of deviance-detecting ensembles, demonstrating a causal role for top-down inputs. The presence of specialized context-selective ensembles in primary sensory cortex, modulated by higher cortical areas, provides a circuit substrate for the brain's construction and selection of prediction errors, computations which are key for survival and deficient in many psychiatric disorders. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Circuits; Neocortex; Predictive coding
语种	英语
scopus关键词	adult; animal cell; animal experiment; animal tissue; Article; brain cortex; cell population; computer model; controlled study; electroencephalogram; evoked cortical response; female; local field potential; male; mental disease; mouse; nerve cell; neuroimaging; nonhuman; optogenetics; prediction; prefrontal cortex; primary somatosensory cortex; priority journal; single cell analysis; striate cortex; survival factor
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179949
作者单位	Department of Biological Sciences, Columbia University, New York, NY 10027, United States
推荐引用方式 GB/T 7714	Hamm J.P.,Shymkiv Y.,Han S.,et al. Cortical ensembles selective for context[J],2021,118(14).
APA	Hamm J.P.,Shymkiv Y.,Han S.,Yang W.,&Yuste R..(2021).Cortical ensembles selective for context.Proceedings of the National Academy of Sciences of the United States of America,118(14).
MLA	Hamm J.P.,et al."Cortical ensembles selective for context".Proceedings of the National Academy of Sciences of the United States of America 118.14(2021).