气候变化领域集成服务门户(CCPortal): Ranking the risk of animal-to-human spillover for newly discovered viruses

CCPortal

DOI	10.1073/pnas.2002324118
	Ranking the risk of animal-to-human spillover for newly discovered viruses
	Grange Z.L.; Goldstein T.; Johnson C.K.; Anthony S.; Gilardi K.; Daszak P.; Olival K.J.; O'Rourke T.; Murray S.; Olson S.H.; Togami E.; Vidal G.; Mazet J.A.K.; PREDICT Consortium
发表日期	2021
ISSN	00278424
卷号	118 期号:15
英文摘要	The death toll and economic loss resulting from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic are stark reminders that we are vulnerable to zoonotic viral threats. Strategies are needed to identify and characterize animal viruses that pose the greatest risk of spillover and spread in humans and inform public health interventions. Using expert opinion and scientific evidence, we identified host, viral, and environmental risk factors contributing to zoonotic virus spillover and spread in humans. We then developed a risk ranking framework and interactive web tool, SpillOver, that estimates a risk score for wildlife-origin viruses, creating a comparative risk assessment of viruses with uncharacterized zoonotic spillover potential alongside those already known to be zoonotic. Using data from testing 509,721 samples from 74,635 animals as part of a virus discovery project and public records of virus detections around the world, we ranked the spillover potential of 887 wildlife viruses. Validating the risk assessment, the top 12 were known zoonotic viruses, including SARS-CoV-2. Several newly detected wildlife viruses ranked higher than known zoonotic viruses. Using a scientifically informed process, we capitalized on the recent wealth of virus discovery data to systematically identify and prioritize targets for investigation. The publicly accessible SpillOver platform can be used by policy makers and health scientists to inform research and public health interventions for prevention and rapid control of disease outbreaks. SpillOver is a living, interactive database that can be refined over time to continue to improve the quality and public availability of information on viral threats to human health. © This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
英文关键词	Disease ecology; Emerging infectious disease; Public health; Wildlife; Zoonotic virus
语种	英语
scopus关键词	animal; communicable disease; human; pandemic; zoonosis; Animals; Communicable Diseases, Emerging; COVID-19; Humans; Pandemics; SARS-CoV-2; Zoonoses
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179939
作者单位	One Health Institute, Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA 95616, United States; EcoHealth Alliance, New York, NY 1001, United States; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, United States; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, United States; Metabiota, Inc., Nanaimo, BC V9S 1G5, Canada; Global Health, Smithsonian Conservation Biology Institute, Washington, DC 20008, United States; Wildlife Conservation Society, New York, NY 10460, United States
推荐引用方式 GB/T 7714	Grange Z.L.,Goldstein T.,Johnson C.K.,et al. Ranking the risk of animal-to-human spillover for newly discovered viruses[J],2021,118(15).
APA	Grange Z.L..,Goldstein T..,Johnson C.K..,Anthony S..,Gilardi K..,...&PREDICT Consortium.(2021).Ranking the risk of animal-to-human spillover for newly discovered viruses.Proceedings of the National Academy of Sciences of the United States of America,118(15).
MLA	Grange Z.L.,et al."Ranking the risk of animal-to-human spillover for newly discovered viruses".Proceedings of the National Academy of Sciences of the United States of America 118.15(2021).