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DOI	10.1073/pnas.2017176118
	The giant axolotl genome uncovers the evolution, scaling, and transcriptional control of complex gene loci
	Schloissnig S.; Kawaguchi A.; Nowoshilow S.; Falcon F.; Otsuki L.; Tardivo P.; Timoshevskaya N.; Keinath M.C.; Smith J.J.; Voss S.R.; Tanaka E.M.
发表日期	2021
ISSN	00278424
卷号	118 期号:15
英文摘要	Vertebrates harbor recognizably orthologous gene complements but vary 100-fold in genome size. How chromosomal organization scales with genome expansion is unclear, and how acute changes in gene regulation, as during axolotl limb regeneration, occur in the context of a vast genome has remained a riddle. Here, we describe the chromosome-scale assembly of the giant, 32 Gb axolotl genome. Hi-C contact data revealed the scaling properties of interphase and mitotic chromosome organization. Analysis of the assembly yielded understanding of the evolution of large, syntenic multigene clusters, including the Major Histocompatibility Complex (MHC) and the functional regulatory landscape of the Fibroblast Growth Factor 8 (Axfgf8) region. The axolotl serves as a primary model for studying successful regeneration. © This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
英文关键词	Axolotl; Genome assembly; Regeneration; Topological associating domains
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179934
作者单位	Vienna Biocenter, Institute of Molecular Pathology (IMP), Vienna, 1030, Austria; Department of Biology, University of Kentucky, Lexington, KY 40506, United States; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40506, United States; Department of Neuroscience, University of Kentucky, Lexington, KY 40506, United States; Ambystoma Genetic Stock Center, University of Kentucky, Lexington, KY 40506, United States
推荐引用方式 GB/T 7714	Schloissnig S.,Kawaguchi A.,Nowoshilow S.,et al. The giant axolotl genome uncovers the evolution, scaling, and transcriptional control of complex gene loci[J],2021,118(15).
APA	Schloissnig S..,Kawaguchi A..,Nowoshilow S..,Falcon F..,Otsuki L..,...&Tanaka E.M..(2021).The giant axolotl genome uncovers the evolution, scaling, and transcriptional control of complex gene loci.Proceedings of the National Academy of Sciences of the United States of America,118(15).
MLA	Schloissnig S.,et al."The giant axolotl genome uncovers the evolution, scaling, and transcriptional control of complex gene loci".Proceedings of the National Academy of Sciences of the United States of America 118.15(2021).