气候变化领域集成服务门户(CCPortal): Primate phageomes are structured by superhost phylogeny and environment

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DOI	10.1073/pnas.2013535118
	Primate phageomes are structured by superhost phylogeny and environment
	Gogarten J.F.; Rühlemann M.; Archie E.; Tung J.; Akoua-Koffi C.; Bang C.; Deschner T.; Muyembe-Tamfun J.-J.; Robbins M.M.; Schubert G.; Surbeck M.; Wittig R.M.; Zuberbühler K.; Baines J.F.; Franke A.; Leendertz F.H.; Calvignac-Spencer S.
发表日期	2021
ISSN	00278424
卷号	118 期号:15
英文摘要	Humans harbor diverse communities of microorganisms, the majority of which are bacteria in the gastrointestinal tract. These gut bacterial communities in turn host diverse bacteriophage (hereafter phage) communities that have a major impact on their structure, function, and, ultimately, human health. However, the evolutionary and ecological origins of these human-associated phage communities are poorly understood. To address this question, we examined fecal phageomes of 23 wild nonhuman primate taxa, including multiple representatives of all the major primate radiations. We find relatives of the majority of human-associated phages in wild primates. Primate taxa have distinct phageome compositions that exhibit a clear phylosymbiotic signal, and phage-superhost codivergence is often detected for individual phages. Within species, neighboring social groups harbor compositionally and evolutionarily distinct phageomes, which are structured by superhost social behavior. Captive nonhuman primate phageome composition is intermediate between that of their wild counterparts and humans. Phage phylogenies reveal replacement of wild great ape-associated phages with human-associated ones in captivity and, surprisingly, show no signal for the persistence of wild-associated phages in captivity. Together, our results suggest that potentially labile primate-phage associations have persisted across millions of years of evolution. Across primates, these phylosymbiotic and sometimes codiverging phage communities are shaped by transmission between groupmates through grooming and are dramatically modified when primates are moved into captivity. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Bacteriophages; Codivergence; Fecal virome; Phylosymbiosis; Zoonotic transmission
语种	英语
scopus关键词	article; bacteriophage; feces; grooming; human; nonhuman; phylogeny; primate; relative; virome; zoonotic transmission
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179897
作者单位	Epidemiology of Highly Pathogenic Organisms, Robert Koch Institute, Berlin, 13353, Germany; Viral Evolution, Robert Koch Institute, Berlin, 13353, Germany; Institute of Clinical Molecular Biology, Christian-Albrecht-University of Kiel, Kiel, 24105, Germany; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, United States; Department of Biology, Duke University, Durham, NC 27708, United States; Population Research Institute, Duke University, Durham, NC 27708, United States; Department of Evolutionary Anthropology, Duke University, Durham, NC 27708, United States; Unité de Formation et Recherche des Sciences Médicales, Université Alassane Ouattara de Bouake, BP V1801, Bouaké, Cote d'Ivoire; Max Planck Institute for Evolutionary Anthropology, Leipzig, 04103, Germany; National Institute for Biomedical Research, National Laboratory of Public Health, BP 1197, Kinshasa, Democratic Republic Congo; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 0213...
推荐引用方式 GB/T 7714	Gogarten J.F.,Rühlemann M.,Archie E.,et al. Primate phageomes are structured by superhost phylogeny and environment[J],2021,118(15).
APA	Gogarten J.F..,Rühlemann M..,Archie E..,Tung J..,Akoua-Koffi C..,...&Calvignac-Spencer S..(2021).Primate phageomes are structured by superhost phylogeny and environment.Proceedings of the National Academy of Sciences of the United States of America,118(15).
MLA	Gogarten J.F.,et al."Primate phageomes are structured by superhost phylogeny and environment".Proceedings of the National Academy of Sciences of the United States of America 118.15(2021).