气候变化领域集成服务门户(CCPortal): Immune cells fold and damage fungal hyphae

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DOI	10.1073/pnas.2020484118
	Immune cells fold and damage fungal hyphae
	Bain J.M.; Alonso M.F.; Childers D.S.; Walls C.A.; Mackenzie K.; Pradhan A.; Lewis L.E.; Louw J.; Avelar G.M.; Larcombe D.E.; Netea M.G.; Gow N.A.R.; Brown G.D.; Erwig L.P.; Brown A.J.P.
发表日期	2021
ISSN	00278424
卷号	118 期号:15
英文摘要	Innate immunity provides essential protection against life-threatening fungal infections. However, the outcomes of individual skirmishes between immune cells and fungal pathogens are not a foregone conclusion because some pathogens have evolved mechanisms to evade phagocytic recognition, engulfment, and killing. For example, Candida albicans can escape phagocytosis by activating cellular morphogenesis to form lengthy hyphae that are challenging to engulf. Through live imaging of C. albicans-macrophage interactions, we discovered that macrophages can counteract this by folding fungal hyphae. The folding of fungal hyphae is promoted by Dectin-1, β2-integrin, VASP, actin-myosin polymerization, and cell motility. Folding facilitates the complete engulfment of long hyphae in some cases and it inhibits hyphal growth, presumably tipping the balance toward successful fungal clearance. © This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
英文关键词	Cytoskeleton; Fungal hyphae; Macrophages; Mechanical force; Podosomes
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179882
作者单位	Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, United Kingdom; Microscopy and Histology Facility, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, United Kingdom; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, EX4 4QD, United Kingdom; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, 6500HB, Netherlands; Department for Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, 53115, Germany; Johnson-Johnson Innovation Europe, Middle East and Africa Innovation Centre, London, W1G 0BG, United Kingdom
推荐引用方式 GB/T 7714	Bain J.M.,Alonso M.F.,Childers D.S.,et al. Immune cells fold and damage fungal hyphae[J],2021,118(15).
APA	Bain J.M..,Alonso M.F..,Childers D.S..,Walls C.A..,Mackenzie K..,...&Brown A.J.P..(2021).Immune cells fold and damage fungal hyphae.Proceedings of the National Academy of Sciences of the United States of America,118(15).
MLA	Bain J.M.,et al."Immune cells fold and damage fungal hyphae".Proceedings of the National Academy of Sciences of the United States of America 118.15(2021).