气候变化领域集成服务门户(CCPortal): MrgprC11+ sensory neurons mediate glabrous skin itch

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DOI	10.1073/pnas.2022874118
	MrgprC11+ sensory neurons mediate glabrous skin itch
	Steele H.R.; Xing Y.; Zhu Y.; Hilley H.B.; Lawson K.; Nho Y.; Niehoff T.; Han L.
发表日期	2021
ISSN	00278424
卷号	118 期号:15
英文摘要	Itch arising from glabrous skin (palms and soles) has attracted limited attention within the field due to the lack of methodology. This is despite glabrous itch arising from many medical conditions such as plantar and palmar psoriasis, dyshidrosis, and cholestasis. Therefore, we developed a mouse glabrous skin behavioral assay to investigate the contribution of three previously identified pruriceptive neurons in glabrous skin itch. Our results show that MrgprA3+ and MrgprD+ neurons, although key mediators for hairy skin itch, do not play important roles in glabrous skin itch, demonstrating a mechanistic difference in itch sensation between hairy and glabrous skin. We found that MrgprC11+ neurons are the major mediators for glabrous skin itch. Activation of MrgprC11+ neurons induced glabrous skin itch, while ablation of MrgprC11+ neurons reduced both acute and chronic glabrous skin itch. Our study provides insights into the mechanisms of itch and opens up new avenues for future glabrous skin itch research. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Glabrous skin; Itch; Mrgprs
语种	英语
scopus关键词	animal cell; animal experiment; article; glabrous skin; male; mouse; nonhuman; sensation; sensory nerve cell
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179864
作者单位	School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, United States
推荐引用方式 GB/T 7714	Steele H.R.,Xing Y.,Zhu Y.,et al. MrgprC11+ sensory neurons mediate glabrous skin itch[J],2021,118(15).
APA	Steele H.R..,Xing Y..,Zhu Y..,Hilley H.B..,Lawson K..,...&Han L..(2021).MrgprC11+ sensory neurons mediate glabrous skin itch.Proceedings of the National Academy of Sciences of the United States of America,118(15).
MLA	Steele H.R.,et al."MrgprC11+ sensory neurons mediate glabrous skin itch".Proceedings of the National Academy of Sciences of the United States of America 118.15(2021).