气候变化领域集成服务门户(CCPortal): Heritable variation in telomere length predicts mortality in Soay sheep

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DOI	10.1073/pnas.2020563118
	Heritable variation in telomere length predicts mortality in Soay sheep
	Froy H.; Underwood S.L.; Dorrens J.; Seeker L.A.; Watt K.; Wilbourn R.V.; Pilkington J.G.; Harrington L.; Pemberton J.M.; Nussey D.H.
发表日期	2021
ISSN	00278424
卷号	118 期号:15
英文摘要	Telomere length (TL) is considered an important biomarker of whole-organism health and aging. Across humans and other vertebrates, short telomeres are associated with increased subsequent mortality risk, but the processes responsible for this correlation remain uncertain. A key unanswered question is whether TL-mortality associations arise due to positive effects of genes or early-life environment on both an individual's average lifetime TL and their longevity, or due to more immediate effects of environmental stressors on within-individual TL loss and increased mortality risk. Addressing this question requires longitudinal TL and life history data across the entire lifetimes of many individuals, which are difficult to obtain for long-lived species like humans. Using longitudinal data and samples collected over nearly two decades, as part of a long-term study of wild Soay sheep, we dissected an observed positive association between TL and subsequent survival using multivariate quantitative genetic models. We found no evidence that telomere attrition was associated with increased mortality risk, suggesting that TL is not an important marker of biological aging or exposure to environmental stress in our study system. Instead, we find that among-individual differences in average TL are associated with increased lifespan. Our analyses suggest that this correlation between an individual's average TL and lifespan has a genetic basis. This demonstrates that TL has the potential to evolve under natural conditions, and suggests an important role of genetics underlying the widespread observation that short telomeres predict mortality. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Aging; Biomarker; Longevity; Senescence; Survival
语种	英语
scopus关键词	aging; Article; controlled study; correlation analysis; environmental factor; environmental stress; female; genetic model; genetic variation; heritability; life history; lifespan; longevity; male; mortality; mortality risk; nonhuman; prediction; priority journal; quantitative analysis; sheep; survival rate; telomere length
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179863
作者单位	Centre for Biodiversity Dynamics, Institute for Biology, Norwegian University for Science and Technology, Trondheim, 7014, Norway; Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3FL, United Kingdom; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC H3C 3J7, Canada
推荐引用方式 GB/T 7714	Froy H.,Underwood S.L.,Dorrens J.,et al. Heritable variation in telomere length predicts mortality in Soay sheep[J],2021,118(15).
APA	Froy H..,Underwood S.L..,Dorrens J..,Seeker L.A..,Watt K..,...&Nussey D.H..(2021).Heritable variation in telomere length predicts mortality in Soay sheep.Proceedings of the National Academy of Sciences of the United States of America,118(15).
MLA	Froy H.,et al."Heritable variation in telomere length predicts mortality in Soay sheep".Proceedings of the National Academy of Sciences of the United States of America 118.15(2021).