气候变化领域集成服务门户(CCPortal): Three-micrometer-diameter needle electrode with an amplifier for extracellular in vivo recordings

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DOI	10.1073/pnas.2008233118
	Three-micrometer-diameter needle electrode with an amplifier for extracellular in vivo recordings
	Kita Y.; Tsuruhara S.; Kubo H.; Yamashita K.; Seikoba Y.; Idogawa S.; Sawahata H.; Yamagiwa S.; Leong X.L.A.; Numano R.; Koida K.; Kawano T.
发表日期	2021
ISSN	00278424
卷号	118 期号:16
英文摘要	Microscale needle-electrode devices offer neuronal signal recording capability in brain tissue; however, using needles of smaller geometry to minimize tissue damage causes degradation of electrical properties, including high electrical impedance and low signal-to-noise ratio (SNR) recording. We overcome these limitations using a device assembly technique that uses a single needle-topped amplifier package, called STACK, within a device of ∼1 × 1 mm2. Based on silicon (Si) growth technology, a <3-μm-tip-diameter, 400-μm-length needle electrode was fabricated on a Si block as the module. The high electrical impedance characteristics of the needle electrode were improved by stacking it on the other module of the amplifier. The STACK device exhibited a voltage gain of >0.98 (−0.175 dB), enabling recording of the local field potential and action potentials from the mouse brain in vivo with an improved SNR of 6.2. Additionally, the device allowed us to use a Bluetooth module to demonstrate wireless recording of these neuronal signals; the chronic experiment was also conducted using STACK-implanted mice. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Microelectrode; MOSFET; Neural recording
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179855
作者单位	Department of Electrical and Electric Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka Tempaku-cho, Toyohashi, 441-8580, Japan; National Institute of Technology, Ibaraki College, 866 Nakane, Hitachinaka, 312-8508, Japan; Department of Applied Chemistry and Life Science, Toyohashi University of Technology, 1-1 Hibarigaoka Tempaku-cho, Toyohashi, 441-8580, Japan; Department of Computer Science and Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka Tempaku-cho, Toyohashi, 441-8580, Japan; Electronics-Inspired Interdisciplinary Research Institute, Toyohashi University of Technology, 1-1 Hibarigaoka Tempaku-cho, Toyohashi, 441-8580, Japan
推荐引用方式 GB/T 7714	Kita Y.,Tsuruhara S.,Kubo H.,et al. Three-micrometer-diameter needle electrode with an amplifier for extracellular in vivo recordings[J],2021,118(16).
APA	Kita Y..,Tsuruhara S..,Kubo H..,Yamashita K..,Seikoba Y..,...&Kawano T..(2021).Three-micrometer-diameter needle electrode with an amplifier for extracellular in vivo recordings.Proceedings of the National Academy of Sciences of the United States of America,118(16).
MLA	Kita Y.,et al."Three-micrometer-diameter needle electrode with an amplifier for extracellular in vivo recordings".Proceedings of the National Academy of Sciences of the United States of America 118.16(2021).