气候变化领域集成服务门户(CCPortal): Interferon regulatory factor 4 controls effector functions of CD8+ memory T cells

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DOI	10.1073/pnas.2014553118
	Interferon regulatory factor 4 controls effector functions of CD8+ memory T cells
	Harberts A.; Schmidt C.; Schmid J.; Reimers D.; Koch-Nolte F.; Mittrücker H.-W.; Raczkowski F.
发表日期	2021
ISSN	00278424
卷号	118 期号:16
英文摘要	The transcription factor IRF4 is required for CD8+ T cell activation, proliferation, and differentiation to effector cells and thus is essential for robust CD8+ T cell responses. The function of IRF4 in memory CD8+ T cells yet needs to be explored. To investigate the role of IRF4 for maintaining differentiation state and survival of CD8+ memory T cells, we used a mouse model with tamoxifen-inducible Irf4 knockout to preclude effects due to inefficient memory cell differentiation in absence of IRF4. We infected mice with ovalbumin-recombinant listeria and induced Irf4 knockout after clearance of the pathogen. Loss of IRF4 resulted in phenotypical changes of CD8+ memory T cells but did not cause a reduction of the total memory T cell population. However, upon reencounter of the pathogen, CD8+ memory T cells showed impaired expansion and acquisition of effector functions. When compared to CD8+ effector memory T cells, CD8+ tissue-resident memory T cells (TRM cells) expressed higher IRF4 levels. Mice with constitutive Irf4 knockout had diminished CD8+ TRM-cell populations, and tamoxifen-induced Irf4 deletion caused a reduction of this cell population. In conclusion, our results demonstrate that IRF4 is required for effective reactivation but not for general survival of CD8+ memory T cells. Formation and maintenance of CD8+ TRM cells, in contrast, appear to depend on IRF4. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	CD8+ T cells; Interferon regulatory factor 4; Listeria monocytogenes; Memory T cells
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179809
作者单位	Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany
推荐引用方式 GB/T 7714	Harberts A.,Schmidt C.,Schmid J.,et al. Interferon regulatory factor 4 controls effector functions of CD8+ memory T cells[J],2021,118(16).
APA	Harberts A..,Schmidt C..,Schmid J..,Reimers D..,Koch-Nolte F..,...&Raczkowski F..(2021).Interferon regulatory factor 4 controls effector functions of CD8+ memory T cells.Proceedings of the National Academy of Sciences of the United States of America,118(16).
MLA	Harberts A.,et al."Interferon regulatory factor 4 controls effector functions of CD8+ memory T cells".Proceedings of the National Academy of Sciences of the United States of America 118.16(2021).