气候变化领域集成服务门户(CCPortal): Parental bias in expression and interaction of genes in the equine placenta

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DOI	10.1073/pnas.2006474118
	Parental bias in expression and interaction of genes in the equine placenta
	Dini P.; Kalbfleisch T.; Uribe-Salazar J.M.; Carossino M.; El-Sheikh Ali H.; Loux S.C.; Esteller-Vico A.; Norris J.K.; Anand L.; Scoggin K.E.; Rodriguez Lopez C.M.; Breen J.; Bailey E.; Daels P.; Ball B.A.
发表日期	2021
ISSN	00278424
卷号	118 期号:16
英文摘要	Most autosomal genes in the placenta show a biallelic expression pattern. However, some genes exhibit allele-specific transcription depending on the parental origin of the chromosomes on which the copy of the gene resides. Parentally expressed genes are involved in the reciprocal interaction between maternal and paternal genes, coordinating the allocation of resources between fetus and mother. One of the main challenges of studying parental-specific allelic expression (allele-specific expression [ASE]) in the placenta is the maternal cellular remnant at the fetomaternal interface. Horses (Equus caballus) have an epitheliochorial placenta in which both the endometrial epithelium and the epithelium of the chorionic villi are juxtaposed with minimal extension into the uterine mucosa, yet there is no information available on the allelic gene expression of equine chorioallantois (CA). In the current study, we present a dataset of 1,336 genes showing ASE in the equine CA (https://pouya-dini.github.io/equine-gene-db/) along with a workflow for analyzing ASE genes. We further identified 254 potentially imprinted genes among the parentally expressed genes in the equine CA and evaluated the expression pattern of these genes throughout gestation. Our gene ontology analysis implies that maternally expressed genes tend to decrease the length of gestation, while paternally expressed genes extend the length of gestation. This study provides fundamental information regarding parental gene expression during equine pregnancy, a species with a negligible amount of maternal cellular remnant in its placenta. This information will provide the basis for a better understanding of the role of parental gene expression in the placenta during gestation. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Allele-specific expression; Equine; Monoallelic gene expression; Parental gene expression; Placenta
语种	英语
scopus关键词	allele; animal experiment; article; chorioallantois; chorion villus; domestic horse; endometrium; female; gene expression; gene ontology; human; nonhuman; pregnancy; workflow
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179799
作者单位	Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40503, United States; Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, 9820, Belgium; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, United States; Department of Biochemistry and Molecular Medicine, Genome Center, Medical Investigation of Neurodevelopmental Disorders Institute, University of California, Davis, CA 95616, United States; Theriogenology Department, Faculty of Veterinary Medicine, University of Mansoura35516, Egypt; Environmental Epigenetics and Genetics Group, Department of Horticulture, University of Kentucky, Lexington, KY 40546, United States; South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia
推荐引用方式 GB/T 7714	Dini P.,Kalbfleisch T.,Uribe-Salazar J.M.,et al. Parental bias in expression and interaction of genes in the equine placenta[J],2021,118(16).
APA	Dini P..,Kalbfleisch T..,Uribe-Salazar J.M..,Carossino M..,El-Sheikh Ali H..,...&Ball B.A..(2021).Parental bias in expression and interaction of genes in the equine placenta.Proceedings of the National Academy of Sciences of the United States of America,118(16).
MLA	Dini P.,et al."Parental bias in expression and interaction of genes in the equine placenta".Proceedings of the National Academy of Sciences of the United States of America 118.16(2021).