气候变化领域集成服务门户(CCPortal): Specific modulation of the root immune system by a community of commensal bacteria

CCPortal

DOI	10.1073/pnas.2100678118
	Specific modulation of the root immune system by a community of commensal bacteria
	Teixeira P.J.P.L.; Colaianni N.R.; Law T.F.; Conway J.M.; Gilbert S.; Li H.; Salas-González I.; Panda D.; Del Risco N.M.; Finkel O.M.; Castrillo G.; Mieczkowski P.; Jones C.D.; Dangl J.L.
发表日期	2021
ISSN	00278424
卷号	118 期号:16
英文摘要	Plants have an innate immune system to fight off potential invaders that is based on the perception of nonself or modified-self molecules. Microbe-associated molecular patterns (MAMPs) are evolutionarily conserved microbial molecules whose extracellular detection by specific cell surface receptors initiates an array of biochemical responses collectively known as MAMP-triggered immunity (MTI). Well-characterized MAMPs include chitin, peptidoglycan, and flg22, a 22-amino acid epitope found in the major building block of the bacterial flagellum, FliC. The importance of MAMP detection by the plant immune system is underscored by the large diversity of strategies used by pathogens to interfere with MTI and that failure to do so is often associated with loss of virulence. Yet, whether or how MTI functions beyond pathogenic interactions is not well understood. Here we demonstrate that a community of root commensal bacteria modulates a specific and evolutionarily conserved sector of the Arabidopsis immune system. We identify a set of robust, taxonomically diverse MTI suppressor strains that are efficient root colonizers and, notably, can enhance the colonization capacity of other tested commensal bacteria. We highlight the importance of extracellular strategies for MTI suppression by showing that the type 2, not the type 3, secretion system is required for the immunomodulatory activity of one robust MTI suppressor. Our findings reveal that root colonization by commensals is controlled by MTI, which, in turn, can be selectively modulated by specific members of a representative bacterial root microbiota. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Flg22; MAMP; Plant immunity; Root microbiome; SynCom
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179788
作者单位	HHMI, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Department of Biology, Kenyon College, Gambier, OH 43022, United States; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
推荐引用方式 GB/T 7714	Teixeira P.J.P.L.,Colaianni N.R.,Law T.F.,et al. Specific modulation of the root immune system by a community of commensal bacteria[J],2021,118(16).
APA	Teixeira P.J.P.L..,Colaianni N.R..,Law T.F..,Conway J.M..,Gilbert S..,...&Dangl J.L..(2021).Specific modulation of the root immune system by a community of commensal bacteria.Proceedings of the National Academy of Sciences of the United States of America,118(16).
MLA	Teixeira P.J.P.L.,et al."Specific modulation of the root immune system by a community of commensal bacteria".Proceedings of the National Academy of Sciences of the United States of America 118.16(2021).