气候变化领域集成服务门户(CCPortal): Parallel evolution of UbiA superfamily proteins into aromatic O-prenyltransferases in plants

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DOI	10.1073/pnas.2022294118
	Parallel evolution of UbiA superfamily proteins into aromatic O-prenyltransferases in plants
	Munakata R.; Olry A.; Takemura T.; Tatsumi K.; Ichino T.; Villard C.; Kageyama J.; Kurata T.; Nakayasu M.; Jacob F.; Koeduka T.; Yamamoto H.; Moriyoshi E.; Matsukawa T.; Grosjean J.; Krieger C.; Sugiyama A.; Mizutani M.; Bourgaud F.; Hehn A.; Yazaki K.
发表日期	2021
ISSN	00278424
卷号	118 期号:17
英文摘要	Plants produce ∼300 aromatic compounds enzymatically linked to prenyl side chains via C–O bonds. These O-prenylated aromatic compounds have been found in taxonomically distant plant taxa, with some of them being beneficial or detrimental to human health. Although their O-prenyl moieties often play crucial roles in the biological activities of these compounds, no plant gene encoding an aromatic O-prenyltransferase (O-PT) has been isolated to date. This study describes the isolation of an aromatic O-PT gene, CpPT1, belonging to the UbiA superfamily, from grapefruit (Citrus × paradisi, Rutaceae). This gene was shown responsible for the biosynthesis of O-prenylated coumarin derivatives that alter drug pharmacokinetics in the human body. Another coumarin O-PT gene encoding a protein of the same family was identified in Angelica keiskei, an apiaceous medicinal plant containing pharmaceutically active O-prenylated coumarins. Phylogenetic analysis of these O-PTs suggested that aromatic O-prenylation activity evolved independently from the same ancestral gene in these distant plant taxa. These findings shed light on understanding the evolution of plant secondary (specialized) metabolites via the UbiA superfamily. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Aromatic O-prenyltransferase; Coumarin; Grapefruit–drug interactions; Parallel evolution; Plant-specialized metabolism
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179768
作者单位	Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Uji, 611–0011, Japan; Laboratoire Agronomie et Environnement, Université de Lorraine, National Institute for Agronomic and Environmental Research, Nancy, F54000, France; EditForce Inc., Fukuoka, 810-0001, Japan; PalmElit SAS, Montferrier sur Lez, 34980, France; Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Yamaguchi, 753-8515, Japan; Department of Applied Biosciences, Faculty of Life Sciences, Toyo University, Itakura, 374-0193, Japan; The Experimental Farm, Kindai University, Wakayama, 643-0004, Japan; Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama, 649-6493, Japan; Functional Phytochemistry, Graduate School of Agricultural Science, Kobe University, Kobe, 657-8501, Japan; Plant Advanced Technologies, Vandoeuvre, 54500, France
推荐引用方式 GB/T 7714	Munakata R.,Olry A.,Takemura T.,et al. Parallel evolution of UbiA superfamily proteins into aromatic O-prenyltransferases in plants[J],2021,118(17).
APA	Munakata R..,Olry A..,Takemura T..,Tatsumi K..,Ichino T..,...&Yazaki K..(2021).Parallel evolution of UbiA superfamily proteins into aromatic O-prenyltransferases in plants.Proceedings of the National Academy of Sciences of the United States of America,118(17).
MLA	Munakata R.,et al."Parallel evolution of UbiA superfamily proteins into aromatic O-prenyltransferases in plants".Proceedings of the National Academy of Sciences of the United States of America 118.17(2021).