气候变化领域集成服务门户(CCPortal): Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement

CCPortal

DOI	10.1073/pnas.2012894118
	Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement
	Nishimoto R.; Derouiche S.; Eto K.; Deveci A.; Kashio M.; Kimori Y.; Matsuoka Y.; Morimatsu H.; Nabekura J.; Tominaga M.
发表日期	2021
ISSN	00278424
卷号	118 期号:17
英文摘要	Microglia maintain central nervous system homeostasis by monitoring changes in their environment (resting state) and by taking protective actions to equilibrate such changes (activated state). These surveillance and protective roles both require constant movement of microglia. Interestingly, induced hypothermia can reduce microglia migration caused by ischemia, suggesting that microglia movement can be modulated by temperature. Although several ion channels and transporters are known to support microglia movement, the precise molecular mechanism that regulates temperature-dependent movement of microglia remains unclear. Some members of the transient receptor potential (TRP) channel superfamily exhibit thermosensitivity and thus are strong candidates for mediation of this phenomenon. Here, we demonstrate that mouse microglia exhibit temperature-dependent movement in vitro and in vivo that is mediated by TRPV4 channels within the physiological range of body temperature. Our findings may provide a basis for future research into the potential clinical application of temperature regulation to preserve cell function via manipulation of ion channel activity. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Microglia; Movement; TRP channels; TRPV4
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179750
作者单位	Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, 444-8787, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, 444-8585, Japan; Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, 700-8558, Japan; Thermal Biology Group, Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki, 444-8787, Japan; Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, 444-8585, Japan; Department of Physiology, Aichi Medical University, Nagakute, 480-1195, Japan; Department of Management and Information Sciences, Faculty of Environmental and Information Sciences, Fukui University of Technology, Fukui, 910-8505, Japan; Department of Anesthesiology and Resuscitology, Okayama University, Graduate School of Medicine, Dentistry, and Pharmace...
推荐引用方式 GB/T 7714	Nishimoto R.,Derouiche S.,Eto K.,et al. Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement[J],2021,118(17).
APA	Nishimoto R..,Derouiche S..,Eto K..,Deveci A..,Kashio M..,...&Tominaga M..(2021).Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement.Proceedings of the National Academy of Sciences of the United States of America,118(17).
MLA	Nishimoto R.,et al."Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement".Proceedings of the National Academy of Sciences of the United States of America 118.17(2021).