气候变化领域集成服务门户(CCPortal): Noninvasive high-frequency oscillations riding spikes delineates epileptogenic sources

CCPortal

DOI	10.1073/pnas.2011130118
	Noninvasive high-frequency oscillations riding spikes delineates epileptogenic sources
	Cai Z.; Sohrabpour A.; Jiang H.; Ye S.; Joseph B.; Brinkmann B.H.; Worrell G.A.; He B.
发表日期	2021
ISSN	00278424
卷号	118 期号:17
英文摘要	High-frequency oscillations (HFOs) are a promising biomarker for localizing epileptogenic brain and guiding successful neurosurgery. However, the utility and translation of noninvasive HFOs, although highly desirable, is impeded by the difficulty in differentiating pathological HFOs from nonepileptiform high-frequency activities and localizing the epileptic tissue using noninvasive scalp recordings, which are typically contaminated with high noise levels. Here, we show that the consistent concurrence of HFOs with epileptiform spikes (pHFOs) provides a tractable means to identify pathological HFOs automatically, and this in turn demarks an epileptiform spike subgroup with higher epileptic relevance than the other spikes in a cohort of 25 temporal epilepsy patients (including a total of 2,967 interictal spikes and 1,477 HFO events). We found significant morphological distinctions of HFOs and spikes in the presence/absence of this concurrent status. We also demonstrated that the proposed pHFO source imaging enhanced localization of epileptogenic tissue by 162% (∼5.36 mm) for concordance with surgical resection and by 186% (∼12.48 mm) with seizure-onset zone determined by invasive studies, compared to conventional spike imaging, and demonstrated superior congruence with the surgical outcomes. Strikingly, the performance of spike imaging was selectively boosted by the presence of spikes with pHFOs, especially in patients with multitype spikes. Our findings suggest that concurrent HFOs and spikes reciprocally discriminate pathological activities, providing a translational tool for noninvasive presurgical diagnosis and postsurgical evaluation in vulnerable patients. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Electrophysiological source imaging; Electrophysiology; Epilepsy; High-frequency oscillations
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179737
作者单位	Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, United States; Department of Neurology and Physiology, Mayo Clinic, Rochester, MN 55905, United States; Department of Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, United States
推荐引用方式 GB/T 7714	Cai Z.,Sohrabpour A.,Jiang H.,et al. Noninvasive high-frequency oscillations riding spikes delineates epileptogenic sources[J],2021,118(17).
APA	Cai Z..,Sohrabpour A..,Jiang H..,Ye S..,Joseph B..,...&He B..(2021).Noninvasive high-frequency oscillations riding spikes delineates epileptogenic sources.Proceedings of the National Academy of Sciences of the United States of America,118(17).
MLA	Cai Z.,et al."Noninvasive high-frequency oscillations riding spikes delineates epileptogenic sources".Proceedings of the National Academy of Sciences of the United States of America 118.17(2021).