气候变化领域集成服务门户(CCPortal): Local adaptation of mycobacterium tuberculosis on the Tibetan plateau

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DOI	10.1073/pnas.2017831118
	Local adaptation of mycobacterium tuberculosis on the Tibetan plateau
	Liu Q.; Liu H.; Shi L.; Gan M.; Zhao X.; Lyu L.-D.; Takiff H.E.; Wan K.; Gao Q.
发表日期	2021
ISSN	00278424
卷号	118 期号:17
英文摘要	During its global dispersal, Mycobacterium tuberculosis (Mtb) has encountered varied geographic environments and host populations. Although local adaptation seems to be a plausible model for describing long-term host–pathogen interactions, genetic evidence for this model is lacking. Here, we analyzed 576 whole-genome sequences of Mtb strains sampled from different regions of high-altitude Tibet. Our results show that, after sequential introduction of a few ancestral strains, the Tibetan Mtb population diversified locally while maintaining strict separation from the Mtb populations on the lower altitude plain regions of China. The current population structure and estimated past population dynamics suggest that the modern Beijing sublineage strains, which expanded over most of China and other global regions, did not show an expansion advantage in Tibet. The mutations in the Tibetan strains showed a higher proportion of A > G/T > C transitions than strains from the plain regions, and genes encoding DNA repair enzymes showed evidence of positive selection. Moreover, the long-term Tibetan exclusive selection for truncating mutations in the thiol-oxidoreductase encoding sseA gene suggests that Mtb was subjected to local selective pressures associated with oxidative stress. Collectively, the population genomics of Mtb strains in the relatively isolated population of Tibet provides genetic evidence that Mtb has adapted to local environments. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Evolution; Local adaptation; Mycobacterium tuberculosis
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179731
作者单位	Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology, The Ministry of Education, Ministry of Health, Chinese Academy of Medical Science (MOE/NHC/CAMS), Shanghai Medical College and School of Basic Medical Sciences, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China; State Key Laboratory for Infectious Diseases Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China; People’s Hospital of Tibet Autonomous Region, Lhasa, 850000, China; Molecular Medical Center, Children’s Hospital of Fudan University, Shanghai, 201102, China; Integrated Mycobacterial Pathogenomics Unit, Institut Pasteur, Paris, 75015, France; Nanshan Center for Chronic Disease Control, Shenzhen, 518054, China; Laboratorio de Genética Molecular, Centro de Microbiología y B...
推荐引用方式 GB/T 7714	Liu Q.,Liu H.,Shi L.,et al. Local adaptation of mycobacterium tuberculosis on the Tibetan plateau[J],2021,118(17).
APA	Liu Q..,Liu H..,Shi L..,Gan M..,Zhao X..,...&Gao Q..(2021).Local adaptation of mycobacterium tuberculosis on the Tibetan plateau.Proceedings of the National Academy of Sciences of the United States of America,118(17).
MLA	Liu Q.,et al."Local adaptation of mycobacterium tuberculosis on the Tibetan plateau".Proceedings of the National Academy of Sciences of the United States of America 118.17(2021).