气候变化领域集成服务门户(CCPortal): HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis

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DOI	10.1073/pnas.2016363118
	HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis
	Nadarajan S.; Altendorfer E.; Saito T.T.; Martinez-Garcia M.; Colaiácovo M.P.
发表日期	2021
ISSN	00278424
卷号	118 期号:17
英文摘要	The position of recombination events established along chromosomes in early prophase I and the chromosome remodeling that takes place in late prophase I are intrinsically linked steps of meiosis that need to be tightly regulated to ensure accurate chromosome segregation and haploid gamete formation. Here, we show that RAD-51 foci, which form at the sites of programmed meiotic DNA double-strand breaks (DSBs), exhibit a biased distribution toward off-centered positions along the chromosomes in wild-type Caenorhabditis elegans, and we identify two meiotic roles for chromatin-associated protein HIM-17 that ensure normal chromosome remodeling in late prophase I. During early prophase I, HIM-17 regulates the distribution of DSB-dependent RAD-51 foci and crossovers on chromosomes, which is critical for the formation of distinct chromosome subdomains (short and long arms of the bivalents) later during chromosome remodeling. During late prophase I, HIM-17 promotes the normal expression and localization of protein phosphatases GSP-1/2 to the surface of the bivalent chromosomes and may promote GSP-1 phosphorylation, thereby antagonizing Aurora B kinase AIR-2 loading on the long arms and preventing premature loss of sister chromatid cohesion. We propose that HIM-17 plays distinct roles at different stages during meiotic progression that converge to promote normal chromosome remodeling and accurate chromosome segregation. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Crossovers; DNA double-strand breaks; HIM-17; Late prophase I remodeling; Meiosis
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179722
作者单位	Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, United States
推荐引用方式 GB/T 7714	Nadarajan S.,Altendorfer E.,Saito T.T.,et al. HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis[J],2021,118(17).
APA	Nadarajan S.,Altendorfer E.,Saito T.T.,Martinez-Garcia M.,&Colaiácovo M.P..(2021).HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis.Proceedings of the National Academy of Sciences of the United States of America,118(17).
MLA	Nadarajan S.,et al."HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis".Proceedings of the National Academy of Sciences of the United States of America 118.17(2021).