气候变化领域集成服务门户(CCPortal): Transcriptional profiling reveals signatures of latent developmental potential in Arabidopsis stomatal lineage ground cells

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DOI	10.1073/pnas.2021682118
	Transcriptional profiling reveals signatures of latent developmental potential in Arabidopsis stomatal lineage ground cells
	Ho C.-M.K.; Bringmann M.; Oshima Y.; Mitsuda N.; Bergmann D.C.
发表日期	2021
ISSN	00278424
卷号	118 期号:17
英文摘要	In many developmental contexts, cell lineages have variable or flexible potency to self-renew. What drives a cell to exit from a proliferative state and begin differentiation, or to retain the capacity to divide days or years later is not clear. Here we exploit the mixed potential of the stomatal lineage ground cell (SLGC) in the Arabidopsis leaf epidermis as a model to explore how cells might balance potential to differentiate with a reentry into proliferation. By generating transcriptomes of fluorescence-activated cell sorting-isolated populations that combinatorically define SLGCs and integrating these data with other stomatal lineage datasets, we find that SLGCs appear poised between proliferation and endoreduplication. Furthermore, we found the RNA polymerase II-related mediator complex interactor DEK and the transcription factor MYB16 accumulate differentially in the stomatal lineage and influence the extent of cell proliferation during leaf development. These findings suggest that SLGC latent potential is maintained by poising of the cell cycle machinery, as well as general and site-specific gene-expression regulators. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Arabidopsis; MYB16 endoreduplication; Stomatal lineage ground cell; Transcriptional profile
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179711
作者单位	Department of Biology, Stanford University, Stanford, CA 94305-5020, United States; Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, 305-8562, Japan; HHMI, Stanford University, Stanford, CA 94305, United States
推荐引用方式 GB/T 7714	Ho C.-M.K.,Bringmann M.,Oshima Y.,et al. Transcriptional profiling reveals signatures of latent developmental potential in Arabidopsis stomatal lineage ground cells[J],2021,118(17).
APA	Ho C.-M.K.,Bringmann M.,Oshima Y.,Mitsuda N.,&Bergmann D.C..(2021).Transcriptional profiling reveals signatures of latent developmental potential in Arabidopsis stomatal lineage ground cells.Proceedings of the National Academy of Sciences of the United States of America,118(17).
MLA	Ho C.-M.K.,et al."Transcriptional profiling reveals signatures of latent developmental potential in Arabidopsis stomatal lineage ground cells".Proceedings of the National Academy of Sciences of the United States of America 118.17(2021).