气候变化领域集成服务门户(CCPortal): Improved bounds on entropy production in living systems

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DOI	10.1073/pnas.2024300118
	Improved bounds on entropy production in living systems
	Skinner D.J.; Dunkel J.
发表日期	2021
ISSN	00278424
卷号	118 期号:18
英文摘要	Living systems maintain or increase local order by working against the second law of thermodynamics. Thermodynamic consistency is restored as they consume free energy, thereby increasing the net entropy of their environment. Recently introduced estimators for the entropy production rate have provided major insights into the efficiency of important cellular processes. In experiments, however, many degrees of freedom typically remain hidden to the observer, and, in these cases, existing methods are not optimal. Here, by reformulating the problem within an optimization framework, we are able to infer improved bounds on the rate of entropy production from partial measurements of biological systems. Our approach yields provably optimal estimates given certain measurable transition statistics. In contrast to prevailing methods, the improved estimator reveals nonzero entropy production rates even when nonequilibrium processes appear time symmetric and therefore may pretend to obey detailed balance. We demonstrate the broad applicability of this framework by providing improved bounds on the energy consumption rates in a diverse range of biological systems including bacterial flagella motors, growing microtubules, and calcium oscillations within human embryonic kidney cells. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Bacterial motors; Calcium oscillations; Entropy production; Markov processes; Microtubules
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179691
作者单位	Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, United States
推荐引用方式 GB/T 7714	Skinner D.J.,Dunkel J.. Improved bounds on entropy production in living systems[J],2021,118(18).
APA	Skinner D.J.,&Dunkel J..(2021).Improved bounds on entropy production in living systems.Proceedings of the National Academy of Sciences of the United States of America,118(18).
MLA	Skinner D.J.,et al."Improved bounds on entropy production in living systems".Proceedings of the National Academy of Sciences of the United States of America 118.18(2021).