气候变化领域集成服务门户(CCPortal): Post-transcriptional tuning of FGF signaling mediates neural crest induction

CCPortal

DOI	10.1073/PNAS.2009997117
	Post-transcriptional tuning of FGF signaling mediates neural crest induction
	Copeland J.; Simoes-Costa M.
发表日期	2021
ISSN	00278424
起始页码	33305
结束页码	33316
卷号	117 期号:52
英文摘要	Ectodermal patterning is required for the establishment of multiple components of the vertebrate body plan. Previous studies have demonstrated that precise combinations of extracellular signals induce distinct ectodermal cell populations, such as the neural crest and the neural plate. Yet, we still lack understanding of how the response to inductive signals is modulated to generate the proper transcriptional output in target cells. Here we show that posttranscriptional attenuation of fibroblast growth factor (FGF) signaling is essential for the establishment of the neural crest territory. We found that neural crest progenitors display elevated expression of DICER, which promotes enhanced maturation of a set of cell-type-specific miRNAs. These miRNAs collectively target components of the FGF signaling pathway, a central player in the process of neural induction in amniotes. Inactivation of this posttranscriptional circuit results in a fate switch, in which neural crest cells are converted into progenitors of the central nervous system. Thus, the posttranscriptional attenuation of signaling systems is a prerequisite for proper segregation of ectodermal cell types. These findings demonstrate how posttranscriptional repression may alter the activity of signaling systems to generate distinct spatial domains of progenitor cells. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	Ectoderm; FGF signaling; MiRNAs; Neural crest; Signaling systems
语种	英语
scopus关键词	fibroblast growth factor; microRNA; ribonuclease III; animal; biological model; cell lineage; chick embryo; cytology; ectoderm; gene expression regulation; genetic transcription; genetics; metabolism; neural crest; signal transduction; stem cell; Animals; Cell Lineage; Chick Embryo; Ectoderm; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; MicroRNAs; Models, Biological; Neural Crest; Ribonuclease III; Signal Transduction; Stem Cells; Transcription, Genetic
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179675
作者单位	Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, United States
推荐引用方式 GB/T 7714	Copeland J.,Simoes-Costa M.. Post-transcriptional tuning of FGF signaling mediates neural crest induction[J],2021,117(52).
APA	Copeland J.,&Simoes-Costa M..(2021).Post-transcriptional tuning of FGF signaling mediates neural crest induction.Proceedings of the National Academy of Sciences of the United States of America,117(52).
MLA	Copeland J.,et al."Post-transcriptional tuning of FGF signaling mediates neural crest induction".Proceedings of the National Academy of Sciences of the United States of America 117.52(2021).