气候变化领域集成服务门户(CCPortal): Identification of Z nucleotides as an ancient signal for two-component system activation in bacteria

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DOI	10.1073/PNAS.2006209117
	Identification of Z nucleotides as an ancient signal for two-component system activation in bacteria
	Vázquez-Ciros O.J.; Alvarez A.F.; Georgellis D.
发表日期	2021
ISSN	00278424
起始页码	33530
结束页码	33539
卷号	117 期号:52
英文摘要	Two-component systems (TCSs) in bacteria are molecular circuits that allow the perception of and response to diverse stimuli. These signaling circuits rely on phosphoryl-group transfers between transmitter and receiver domains of sensor kinase and response regulator proteins, and regulate several cellular processes in response to internal or external cues. Phosphorylation, and thereby activation, of response regulators has been demonstrated to occur by their cognate histidine kinases but also by low molecular weight phosphodonors such as acetyl phosphate and carbamoyl phosphate. Here, we present data indicating that the intermediates of the de novo syntheses of purines and histidine, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5′-monophosphate (ZMP) and/or 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5′-triphosphate (ZTP), activate the response regulator UvrY, by promoting its autophosphorylation at the conserved aspartate at position 54. Moreover, these Z nucleotides are shown to also activate the nonrelated response regulators ArcA, CpxR, RcsB, and PhoQ. We propose that ZMP and/ or ZTP act as alarmones for a wide range of response regulators in vivo, providing a novel mechanism by which they could impact gene expression in response to metabolic cues. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	AICAR; Phosphorylation; Response regulator; Two-component systems; UvrY
语种	英语
scopus关键词	bacterial protein; nucleotide; phosphate; bacterial gene; drug effect; Escherichia coli; gene expression regulation; genetics; metabolism; mutation; phosphorylation; signal transduction; Bacterial Proteins; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Bacterial; Mutation; Nucleotides; Phosphates; Phosphorylation; Signal Transduction
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179668
作者单位	Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de Mexico, Ciudad de Mexico, 04510, Mexico
推荐引用方式 GB/T 7714	Vázquez-Ciros O.J.,Alvarez A.F.,Georgellis D.. Identification of Z nucleotides as an ancient signal for two-component system activation in bacteria[J],2021,117(52).
APA	Vázquez-Ciros O.J.,Alvarez A.F.,&Georgellis D..(2021).Identification of Z nucleotides as an ancient signal for two-component system activation in bacteria.Proceedings of the National Academy of Sciences of the United States of America,117(52).
MLA	Vázquez-Ciros O.J.,et al."Identification of Z nucleotides as an ancient signal for two-component system activation in bacteria".Proceedings of the National Academy of Sciences of the United States of America 117.52(2021).