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DOI | 10.1073/PNAS.2001976117 |
AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes | |
Yang C.; Yin L.; Xie F.; Ma M.; Huang S.; Zeng Y.; Shen W.-H.; Dong A.; Li L. | |
发表日期 | 2021 |
ISSN | 00278424 |
起始页码 | 33679 |
结束页码 | 33688 |
卷号 | 117期号:52 |
英文摘要 | Photomorphogenesis is a critical developmental process bridging light-regulated transcriptional reprogramming with morphological changes in organisms. Strikingly, the chromatin-based transcriptional control of photomorphogenesis remains poorly understood. Here, we show that the Arabidopsis (Arabidopsis thaliana) ortholog of ATP-dependent chromatin-remodeling factor AtINO80 represses plant photomorphogenesis. Loss of AtINO80 inhibited hypocotyl cell elongation and caused anthocyanin accumulation. Both light-induced genes and dark-induced genes were affected in the atino80 mutant. Genome-wide occupancy of the H2A.Z histone variant and levels of histone H3 were reduced in atino80. In particular, AtINO80 bound the gene body of ELONGATED HYPOCOTYL 5 (HY5), resulting in lower chromatin incorporations of H2A.Z and H3 at HY5 in atino80. Genetic analysis revealed that AtINO80 acts in a phytochrome B- and HY5-dependent manner in the regulation of photomorphogenesis. Together, our study elucidates a mechanism wherein AtINO80 modulates nucleosome density and H2A.Z incorporation and represses the transcription of light-related genes, such as HY5, to fine tune plant photomorphogenesis. © 2020 National Academy of Sciences. All rights reserved. |
英文关键词 | AtINO80; H2A.Z; Nucleosome; Photomorphogenesis; Transcription |
语种 | 英语 |
scopus关键词 | histone H2AZ; histone H3; transcriptome; Arabidopsis protein; H2A.Z protein, Arabidopsis; histone; transcriptome; Arabidopsis thaliana; Article; AtINO80 gene; cell density; chromatin; controlled study; gene control; gene expression; gene function; gene repression; genetic transcription and translation; HY5 gene; nonhuman; nucleosome; overlapping gene; photomorphogenesis; plant gene; priority journal; quantitative analysis; real time polymerase chain reaction; Arabidopsis; darkness; gene expression regulation; genetics; light; metabolism; morphogenesis; mutation; nucleosome; plant gene; radiation response; Arabidopsis; Arabidopsis Proteins; Darkness; Gene Expression Regulation, Plant; Genes, Plant; Histones; Light; Morphogenesis; Mutation; Nucleosomes; Transcriptome |
来源期刊 | Proceedings of the National Academy of Sciences of the United States of America |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/179642 |
作者单位 | State Key Laboratory of Genetic Engineering and Institute of Plant Biology, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, 200438, China; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, 200438, China; Institut de Biologie Moléculaire des Plantes, CNRS, Université de Strasbourg, Strasbourg, 67084, France |
推荐引用方式 GB/T 7714 | Yang C.,Yin L.,Xie F.,et al. AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes[J],2021,117(52). |
APA | Yang C..,Yin L..,Xie F..,Ma M..,Huang S..,...&Li L..(2021).AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes.Proceedings of the National Academy of Sciences of the United States of America,117(52). |
MLA | Yang C.,et al."AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes".Proceedings of the National Academy of Sciences of the United States of America 117.52(2021). |
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