气候变化领域集成服务门户(CCPortal): A noble electrochemical sensor based on TiO2@CuO-N-rGO and poly (L-cysteine) nanocomposite applicable for trace analysis of flunitrazepam

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DOI	10.1016/j.msec.2020.111300
	A noble electrochemical sensor based on TiO2@CuO-N-rGO and poly (L-cysteine) nanocomposite applicable for trace analysis of flunitrazepam
	Sohouli E.; Ghalkhani M.; Rostami M.; Rahimi-Nasrabadi M.; Ahmadi F.
发表日期	2020
ISSN	9284931
卷号	117
英文摘要	Flunitrazepam or date rape medication with trade name of Rohypnol belongs to the benzodiazepines branch that is used as a sedative, anesthetic, anticonvulsant, muscle relaxant, and antianxiety drug. It is known as “drug of aggression” because of its very strong and long-lasting effects on the central nervous system. The sedative influence of flunitrazepam drug increases with alcohol drinking, which causes mental and motor disorders and causes the victim to become silent. Due to its criminals use, its accurate measurement is crucial. In this work, a novel electrochemical sensor based on TiO2@CuO-N doped rGO, TiO2@CuO-N-rGO, nano-composite and poly (L-cysteine), poly (L-Cys), is presented for trace analysis of flunitrazepam in aqueous solution. At first, TiO2@CuO-N-rGO nano-composite was synthesized by the sol-gel method and characterized by Raman spectroscopy, Fourier transform infrared, field emission scanning electron microscope, and X-ray diffraction analysis. Then, the suspension of the TiO2@CuO-N-rGO nano-composite was drop casted on the surface of the glassy carbon electrode (GCE/TiO2@CuO-N-rGO). After that, electro-polymerization of l-cysteine on the GCE/TiO2@CuO-N-rGO surface was performed by cyclic voltammetry (CV) method. The electrochemical characteristics of the GCE/TiO2@CuO-N-rGO/poly (L-Cys) surface were evaluated in the solution of ferri/ferrocyanide by electrochemical impedance spectroscopy (EIS) and CV techniques. The increase in current, change in oxidation peak potential, and the appearance of two reduction peaks indicated higher electron transfer rate with well-performed electrochemical process of flunitrazepam at the modified electrode surface compared to the bare GCE. These improvements originate from the synergistic effect of TiO2@CuO-N-rGO nano-composite and poly (L-Cys). Finally, a linear relationship was resulted between the oxidation peak current and the concentration of flunitrazepam in the wide concentration range of 1 nM to 50 μM with a detection limit of 0.3 nM. © 2020 Elsevier B.V.
英文关键词	Benzodiazepines; Flunitrazepam; L-cysteine; Rohypnol; Synergistic effect; TiO2@CuO-N-rGO; Voltammetry
scopus关键词	Amino acids; Copper oxides; Cyclic voltammetry; Doping (additives); Electrochemical impedance spectroscopy; Glass membrane electrodes; Nanosensors; Oxide minerals; Reduced Graphene Oxide; Scanning electron microscopy; Sol-gel process; Sol-gels; TiO2 nanoparticles; Titanium dioxide; Trace analysis; X ray powder diffraction; Central nervous systems; Electrochemical characteristics; Electrochemical process; Electron transfer rates; Field emission scanning electron microscopes; Fourier transform infra reds; Glassy carbon electrodes; Modified electrode surfaces; Electrochemical sensors
来源期刊	Materials Science and Engineering C
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/176737
作者单位	Halal Research Center of IRI, FDA, Tehran, Iran; Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Iran; Department of Chemistry, Faculty of Science, Shahid Rajaee Teacher Training University, Lavizan, Tehran, 16788, Iran; Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran; Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran; Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran
推荐引用方式 GB/T 7714	Sohouli E.,Ghalkhani M.,Rostami M.,et al. A noble electrochemical sensor based on TiO2@CuO-N-rGO and poly (L-cysteine) nanocomposite applicable for trace analysis of flunitrazepam[J],2020,117.
APA	Sohouli E.,Ghalkhani M.,Rostami M.,Rahimi-Nasrabadi M.,&Ahmadi F..(2020).A noble electrochemical sensor based on TiO2@CuO-N-rGO and poly (L-cysteine) nanocomposite applicable for trace analysis of flunitrazepam.Materials Science and Engineering C,117.
MLA	Sohouli E.,et al."A noble electrochemical sensor based on TiO2@CuO-N-rGO and poly (L-cysteine) nanocomposite applicable for trace analysis of flunitrazepam".Materials Science and Engineering C 117(2020).