气候变化领域集成服务门户(CCPortal): Smoldering and flaming biomass wood smoke inhibit respiratory responses in mice

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DOI	10.1080/08958378.2019.1654046
	Smoldering and flaming biomass wood smoke inhibit respiratory responses in mice
	Hargrove M.M.; Kim Y.H.; King C.; Wood C.E.; Gilmour M.I.; Dye J.A.; Gavett S.H.
发表日期	2019
ISSN	8958378
起始页码	236
结束页码	247
卷号	31 期号:6
英文摘要	Background: Acute and chronic exposures to biomass wildfire smoke pose significant health risks to firefighters and impacted communities. Susceptible populations such as asthmatics may be particularly sensitive to wildfire effects. We examined pulmonary responses to biomass smoke generated from combustion of peat, oak, or eucalyptus in control and house dust mite (HDM)-allergic mice. Methods: Mice were exposed 1 h/d for 2 consecutive days to emissions from each fuel type under smoldering or flaming conditions (∼40 or ∼3.3 mg PM/m3, respectively) while maintaining comparable CO levels (∼60–120 ppm). Results: Control and allergic mice reduced breathing frequency during exposure to all biomass emissions compared with pre-exposure to clean air. Smoldering eucalyptus and oak, but not peat, further reduced frequency compared to flaming conditions in control and allergic groups, while also reducing minute volume and peak inspiratory flow in control mice. Several biochemical and cellular markers of lung injury and inflammation were suppressed by all biomass emission types in both HDM-allergic and control mice. Control mice exposed to flaming eucalyptus at different PM concentrations (C) and times (T) with the same C × T product had a greater decrease in breathing frequency with high concentration acute exposure compared with lower concentration episodic exposure. This decrease was ameliorated by PM HEPA filtration, indicating that the respiratory changes were partially mediated by biomass smoke particles. Conclusion: These data show that exposure to smoldering eucalyptus or oak smoke inhibits respiratory responses to a greater degree than peat smoke. Anti-inflammatory effects of CO may possibly contribute to smoke-induced suppression of allergic inflammatory responses. ©, This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 USC. 105, no copyright protection is available for such works under US Law.
英文关键词	asthma; biomass burning; lung inflammation; pulmonary function; Wood smoke
scopus关键词	carbon dioxide; carbon monoxide; eotaxin; interleukin 13; interleukin 4; interleukin 5; nitrogen oxide; allergen; cytokine; house dust allergen; acute lung injury; adult; animal experiment; animal model; animal tissue; Article; biomass; breathing; breathing rate; bronchoalveolar lavage fluid; combustion; controlled study; Eucalyptus; Eucalyptus globulus; expiratory flow rate; female; filtration; histopathology; house dust allergy; inflammation; lung minute volume; mouse; nonhuman; oak; particle size; particulate matter; peak inspiratory flow; priority journal; smoke; tidal volume; wood; young adult; animal; Bagg albino mouse; cytology; hypersensitivity; immunology; lung; lung function test; macrophage; neutrophil; pathology; pathophysiology; soil; Allergens; Animals; Antigens, Dermatophagoides; Biomass; Bronchoalveolar Lavage Fluid; Cytokines; Eucalyptus; Female; Hypersensitivity; Lung; Macrophages; Mice, Inbred BALB C; Neutrophils; Quercus; Respiratory Function Tests; Smoke; Soil; Wood
来源期刊	Inhalation Toxicology
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/176428
作者单位	Oak Ridge Institute for Science and Education, Research Triangle Park, NC, United States; National Research Council, Washington, DC, United States; National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States; Syngenta, Greensboro, NC, United States; University of North Carolina, Chapel Hill, NC, United States; Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT, United States
推荐引用方式 GB/T 7714	Hargrove M.M.,Kim Y.H.,King C.,et al. Smoldering and flaming biomass wood smoke inhibit respiratory responses in mice[J],2019,31(6).
APA	Hargrove M.M..,Kim Y.H..,King C..,Wood C.E..,Gilmour M.I..,...&Gavett S.H..(2019).Smoldering and flaming biomass wood smoke inhibit respiratory responses in mice.Inhalation Toxicology,31(6).
MLA	Hargrove M.M.,et al."Smoldering and flaming biomass wood smoke inhibit respiratory responses in mice".Inhalation Toxicology 31.6(2019).