气候变化领域集成服务门户(CCPortal): Evaluation of plant sources for antiinfective lead compound discovery by correlating phylogenetic; spatial; and bioactivity data

CCPortal

DOI	10.1073/pnas.1915277117
	Evaluation of plant sources for antiinfective lead compound discovery by correlating phylogenetic; spatial; and bioactivity data
	Holzmeyer L.; Hartig A.-K.; Franke K.; Brandt W.; Muellner-Riehl A.N.; Wessjohann L.A.; Schnitzler J.
发表日期	2020
ISSN	0027-8424
起始页码	12444
结束页码	12451
卷号	117 期号:22
英文摘要	Antibiotic resistance and viral diseases are rising around the world and are becoming major threats to global health, food security, and development. One measure that has been suggested to mitigate this crisis is the development of new antibiotics. Here, we provide a comprehensive evaluation of the phylogenetic and biogeographic patterns of antiinfective compounds from seed plants in one of the most species-rich regions on Earth and identify clades with naturally occurring substances potentially suitable for the development of new pharmaceutical compounds. Specifically, we combine taxonomic and phylogenetic data for >7,500 seed plant species from the flora of Java with >16,500 secondary metabolites and 6,255 georeferenced occurrence records to 1) identify clades in the phylogeny that are characterized by either an over-representation ("hot clades") or an underrepresentation ("cold clades") of antiinfective compounds and 2) assess the spatial patterns of plants with antiinfective compounds relative to total plant diversity across the region. Across the flora of Java, we identify 26 "hot clades" with plant species providing a high probability of finding antibiotic constituents. In addition, 24 "cold clades" constitute lineages with low numbers of reported activities but which have the potential to yield novel compounds. Spatial patterns of plant species and metabolite diversity are strongly correlated across Java, indicating that regions of highest species diversity afford the highest potential to discover novel natural products. Our results indicate that the combination of phylogenetic, spatial, and phytochemical information is a useful tool to guide the selection of taxa for efforts aimed at lead compound discovery. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	Biodiversity; Chemical diversity; Chemoinformatics; Natural products; Phylogenetics
语种	英语
scopus关键词	alkaloid; anthracene; antiinfective agent; benzofuran derivative; coumarin; fatty acid ester; flavonoid; fluorene; isoflavonoid; lactam; lacton; macrocyclic compound; natural product; peptide; peptoid; phenanthrene; phenol derivative; phenylpropanoid; plant extract; polyacetylene; polyketide; quinone derivative; steroid; sugar; terpene; unclassified drug; xanthone derivative; antiinfective agent; lead; antibacterial activity; Article; biogeography; bioprospecting; cladistics; controlled study; drug research; drug screening; geographic mapping; Indonesia; molecular phylogeny; phytochemistry; plant; plant seed; priority journal; probability; spatial analysis; species diversity; taxonomy; biodiversity; chemistry; classification; genetics; metabolism; phylogeny; Anti-Infective Agents; Biodiversity; Lead; Phylogeny; Plants
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160943
作者单位	Holzmeyer, L., Department of Molecular Evolution and Plant Systematics & Herbarium (LZ), Institute of Biology, Leipzig University, Leipzig, D-04103, Germany; Hartig, A.-K., Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), D-06120, Germany; Franke, K., Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), D-06120, Germany; Brandt, W., Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), D-06120, Germany; Muellner-Riehl, A.N., Department of Molecular Evolution and Plant Systematics & Herbarium (LZ), Institute of Biology, Leipzig University, Leipzig, D-04103, Germany, German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Leipzig, D-04103, Germany; Wessjohann, L.A., Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), D-06120, Germany, German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Leipzig, D-0410...
推荐引用方式 GB/T 7714	Holzmeyer L.,Hartig A.-K.,Franke K.,et al. Evaluation of plant sources for antiinfective lead compound discovery by correlating phylogenetic; spatial; and bioactivity data[J],2020,117(22).
APA	Holzmeyer L..,Hartig A.-K..,Franke K..,Brandt W..,Muellner-Riehl A.N..,...&Schnitzler J..(2020).Evaluation of plant sources for antiinfective lead compound discovery by correlating phylogenetic; spatial; and bioactivity data.Proceedings of the National Academy of Sciences of the United States of America,117(22).
MLA	Holzmeyer L.,et al."Evaluation of plant sources for antiinfective lead compound discovery by correlating phylogenetic; spatial; and bioactivity data".Proceedings of the National Academy of Sciences of the United States of America 117.22(2020).