气候变化领域集成服务门户(CCPortal): Ecological divergence and hybridization of Neotropical Leishmania parasites

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DOI	10.1073/pnas.1920136117
	Ecological divergence and hybridization of Neotropical Leishmania parasites
	Van den Broeck F.; Savill N.J.; Imamura H.; Sanders M.; Maes I.; Cooper S.; Mateus D.; Jara M.; Adaui V.; Arevalo J.; Llanos-Cuentas A.; Garcia L.; Cupolillo E.; Miles M.; Berriman M.; Schnaufer A.; Cotton J.A.; Dujardin J.-C.
发表日期	2020
ISSN	0027-8424
起始页码	25159
结束页码	25168
卷号	117 期号:40
英文摘要	The tropical Andes are an important natural laboratory to understand speciation in many taxa. Here we examined the evolutionary history of parasites of the Leishmania braziliensis species complex based on whole-genome sequencing of 67 isolates from 47 localities in Peru. We first show the origin of Andean Leishmania as a clade of near-clonal lineages that diverged from admixed Amazonian ancestors, accompanied by a significant reduction in genome diversity and large structural variations implicated in host-parasite interactions. Within the Andean species, patterns of population structure were strongly associated with biogeographical origin. Molecular clock and ecological niche modeling suggested that the history of diversification of the Andean lineages is limited to the Late Pleistocene and intimately associated with habitat contractions driven by climate change. These results suggest that changes in forestation over the past 150,000 y have influenced speciation and diversity of these Neotropical parasites. Second, genome-scale analyses provided evidence of meiotic-like recombination between Andean and Amazonian Leishmania species, resulting in full-genome hybrids. The mitochondrial genome of these hybrids consisted of homogeneous uniparental maxicircles, but minicircles originated from both parental species. We further show that mitochondrial minicircles- but not maxicircles-show a similar evolutionary pattern to the nuclear genome, suggesting that compatibility between nuclearencoded mitochondrial genes and minicircle-encoded guide RNA genes is essential to maintain efficient respiration. By comparing full nuclear and mitochondrial genome ancestries, our data expand our appreciation on the genetic consequences of diversification and hybridization in parasitic protozoa. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	Ecological speciation; Interspecific hybridization; Population genomics; Speciation genomics; Vector-borne disease
语种	英语
scopus关键词	ecosystem; forest; genetics; host parasite interaction; human; Leishmania braziliensis; mitochondrial genome; parasitology; pathogenicity; Peru; phylogeography; skin leishmaniasis; species differentiation; Ecosystem; Forests; Genetic Speciation; Genome, Mitochondrial; Host-Parasite Interactions; Humans; Leishmania braziliensis; Leishmaniasis, Cutaneous; Peru; Phylogeography
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160784
作者单位	Van den Broeck, F., Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, 2000, Belgium, Department of Microbiology Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, 3000, Belgium; Savill, N.J., Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, EH8 9YL, United Kingdom; Imamura, H., Centre of Medical Genetics, Universitair Ziekenhuis Brussel, Brussels, 1000, Belgium; Sanders, M., Parasite Genomics Group, Wellcome Sanger Institute, Hinxton, CB10, United Kingdom; Maes, I., Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, 2000, Belgium; Cooper, S., Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, EH8 9YL, United Kingdom; Mateus, D., Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom; Jara, M., Department of Biomedical Sciences, Institute of Tropical Medicine, An...
推荐引用方式 GB/T 7714	Van den Broeck F.,Savill N.J.,Imamura H.,et al. Ecological divergence and hybridization of Neotropical Leishmania parasites[J],2020,117(40).
APA	Van den Broeck F..,Savill N.J..,Imamura H..,Sanders M..,Maes I..,...&Dujardin J.-C..(2020).Ecological divergence and hybridization of Neotropical Leishmania parasites.Proceedings of the National Academy of Sciences of the United States of America,117(40).
MLA	Van den Broeck F.,et al."Ecological divergence and hybridization of Neotropical Leishmania parasites".Proceedings of the National Academy of Sciences of the United States of America 117.40(2020).