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DOI10.1073/pnas.2013694117
The role of “spillover” in antibiotic resistance
Olesen S.W.; Lipsitch M.; Grad Y.H.
发表日期2020
ISSN0027-8424
起始页码29063
结束页码29068
卷号117期号:46
英文摘要Antibiotic use is a key driver of antibiotic resistance. Understanding the quantitative association between antibiotic use and resulting resistance is important for predicting future rates of antibiotic resistance and for designing antibiotic stewardship policy. However, the use–resistance association is complicated by “spillover,” in which one population’s level of antibiotic use affects another population’s level of resistance via the transmission of bacteria between those populations. Spillover is known to have effects at the level of families and hospitals, but it is unclear if spillover is relevant at larger scales. We used mathematical modeling and analysis of observational data to address this question. First, we used dynamical models of antibiotic resistance to predict the effects of spillover. Whereas populations completely isolated from one another do not experience any spillover, we found that if even 1% of interactions are between populations, then spillover may have large consequences: The effect of a change in antibiotic use in one population on antibiotic resistance in that population could be reduced by as much as 50%. Then, we quantified spillover in observational antibiotic use and resistance data from US states and European countries for three pathogen–antibiotic combinations, finding that increased interactions between populations were associated with smaller differences in antibiotic resistance between those populations. Thus, spillover may have an important impact at the level of states and countries, which has ramifications for predicting the future of antibiotic resistance, designing antibiotic resistance stewardship policy, and interpreting stewardship interventions. © 2020 National Academy of Sciences. All rights reserved.
英文关键词Antibiotic resistance | antibiotic stewardship | Streptococcus pneumoniae | Escherichia coli
语种英语
scopus关键词beta lactam; macrolide; quinoline derived antiinfective agent; antibiotic resistance; antimicrobial stewardship; Article; bacterial transmission; drug use; Escherichia coli; Europe; mathematical model; observational method; priority journal; simulation; social interaction; social isolation; Streptococcus pneumoniae; United States
来源期刊Proceedings of the National Academy of Sciences of the United States of America
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/160728
作者单位Olesen, S.W., Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, United States; Lipsitch, M., Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, United States, Center for Communicable DiseaseDynamics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, United States; Grad, Y.H., Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, United States, Division of Infectious Diseases, Department of Medicine, Brigham, Women’s Hospital, Harvard Medical School, Boston, MA 02115, United States
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GB/T 7714
Olesen S.W.,Lipsitch M.,Grad Y.H.. The role of “spillover” in antibiotic resistance[J],2020,117(46).
APA Olesen S.W.,Lipsitch M.,&Grad Y.H..(2020).The role of “spillover” in antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America,117(46).
MLA Olesen S.W.,et al."The role of “spillover” in antibiotic resistance".Proceedings of the National Academy of Sciences of the United States of America 117.46(2020).
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