气候变化领域集成服务门户(CCPortal): Polar delivery of Legionella type IV secretion system substrates is essential for virulence

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DOI	10.1073/pnas.1621438114
	Polar delivery of Legionella type IV secretion system substrates is essential for virulence
	Jeong K.C.; Ghosal D.; Chang Y.-W.; Jensen G.J.; Vogel J.P.
发表日期	2017
ISSN	0027-8424
起始页码	8077
结束页码	8082
卷号	114 期号:30
英文摘要	A recurrent emerging theme is the targeting of proteins to subcellular microdomains within bacterial cells, particularly to the poles. In most cases, it has been assumed that this localization is critical to the protein’s function. Legionella pneumophila uses a type IVB secretion system (T4BSS) to export a large number of protein substrates into the cytoplasm of host cells. Here we show that the Legionella export apparatus is localized to the bacterial poles, as is consistent with many T4SS substrates being retained on the phagosomal membrane adjacent to the poles of the bacterium. More significantly, we were able to demonstrate that polar secretion of substrates is critically required for Legionella’s alteration of the host endocytic pathway, an activity required for this pathogen’s virulence. © 2017, National Academy of Sciences. All rights reserved.
英文关键词	Bacterial pathogen; Macrophage; Polar localization; Secretion
语种	英语
scopus关键词	Article; bacterial virulence; cell division; cellular distribution; host cell; Legionella pneumophila; nonhuman; phagosome; polar body; priority journal; type IV secretion system; animal; cell polarity; female; Legionella pneumophila; metabolism; mouse; pathogenicity; physiology; type IV secretion system; Animals; Cell Division; Cell Polarity; Female; Legionella pneumophila; Mice; Type IV Secretion Systems
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160608
作者单位	Jeong, K.C., Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, United States, Department of Animal Sciences and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32611, United States; Ghosal, D., Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States; Chang, Y.-W., Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States; Jensen, G.J., Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, United States; Vogel, J.P., Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, United States
推荐引用方式 GB/T 7714	Jeong K.C.,Ghosal D.,Chang Y.-W.,et al. Polar delivery of Legionella type IV secretion system substrates is essential for virulence[J],2017,114(30).
APA	Jeong K.C.,Ghosal D.,Chang Y.-W.,Jensen G.J.,&Vogel J.P..(2017).Polar delivery of Legionella type IV secretion system substrates is essential for virulence.Proceedings of the National Academy of Sciences of the United States of America,114(30).
MLA	Jeong K.C.,et al."Polar delivery of Legionella type IV secretion system substrates is essential for virulence".Proceedings of the National Academy of Sciences of the United States of America 114.30(2017).