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DOI	10.1073/pnas.1620179114
	Foldamer hypothesis for the growth and sequence differentiation of prebiotic polymers
	Guseva E.; Zuckermann R.N.; Dill K.A.
发表日期	2017
ISSN	0027-8424
起始页码	E7460
结束页码	E7468
卷号	114 期号:36
英文摘要	It is not known how life originated. It is thought that prebiotic processes were able to synthesize short random polymers. However, then, how do short-chain molecules spontaneously grow longer? Also, how would random chains grow more informational and become autocatalytic (i.e., increasing their own concentrations)? We study the folding and binding of random sequences of hydrophobic (H) and polar (P) monomers in a computational model. We find that even short hydrophobic polar (HP) chains can collapse into relatively compact structures, exposing hydrophobic surfaces. In this way, they act as primitive versions of today’s protein catalysts, elongating other such HP polymers as ribosomes would now do. Such foldamer catalysts are shown to form an autocatalytic set, through which short chains grow into longer chains that have particular sequences. An attractive feature of this model is that it does not overconverge to a single solution; it gives ensembles that could further evolve under selection. This mechanism describes how specific sequences and conformations could contribute to the chemistry-to-biology (CTB) transition. © 2017, National Academy of Sciences. All rights reserved.
英文关键词	Autocatalytic sets; Biopolymers; HP model; Origin of life
语种	英语
scopus关键词	monomer; polymer; prebiotic agent; protein; polymer; prebiotic agent; Article; catalysis; catalyst; chemical binding; hydrophobicity; molecular dynamics; molecular model; polymerization; priority journal; ribosome; biogenesis; chemical phenomena; chemistry; polymerization; protein folding; Catalysis; Hydrophobic and Hydrophilic Interactions; Origin of Life; Polymerization; Polymers; Prebiotics; Protein Folding; Proteins
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160599
作者单位	Guseva, E., Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794, United States, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794, United States, Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794, United States; Zuckermann, R.N., Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States; Dill, K.A., Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794, United States, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794, United States, Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794, United States
推荐引用方式 GB/T 7714	Guseva E.,Zuckermann R.N.,Dill K.A.. Foldamer hypothesis for the growth and sequence differentiation of prebiotic polymers[J],2017,114(36).
APA	Guseva E.,Zuckermann R.N.,&Dill K.A..(2017).Foldamer hypothesis for the growth and sequence differentiation of prebiotic polymers.Proceedings of the National Academy of Sciences of the United States of America,114(36).
MLA	Guseva E.,et al."Foldamer hypothesis for the growth and sequence differentiation of prebiotic polymers".Proceedings of the National Academy of Sciences of the United States of America 114.36(2017).