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DOI	10.1073/pnas.1705833114
	Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root
	Di Mambro R.; De Ruvo M.; Pacifici E.; Salvi E.; Sozzani R.; Benfey P.N.; Busch W.; Novak O.; Ljung K.; Di Paola L.; Marée A.F.M.; Costantino P.; Grieneisen V.A.; Sabatini S.
发表日期	2017
ISSN	0027-8424
起始页码	E7641
结束页码	E7649
卷号	114 期号:36
英文摘要	In multicellular organisms, a stringent control of the transition between cell division and differentiation is crucial for correct tissue and organ development. In the Arabidopsis root, the boundary between dividing and differentiating cells is positioned by the antagonistic interaction of the hormones auxin and cytokinin. Cytokinin affects polar auxin transport, but how this impacts the positional information required to establish this tissue boundary, is still unknown. By combining computational modeling with molecular genetics, we show that boundary formation is dependent on cytokinin’s control on auxin polar transport and degradation. The regulation of both processes shapes the auxin profile in a well-defined auxin minimum. This auxin minimum positions the boundary between dividing and differentiating cells, acting as a trigger for this developmental transition, thus controlling meristem size. © 2017, National Academy of Sciences. All rights reserved.
英文关键词	Cell differentiation; Computational modeling; Plant hormones; Root meristem
语种	英语
scopus关键词	Arabidopsis protein; auxin; cytokinin; Arabidopsis protein; cytokinin; indoleacetic acid derivative; phytohormone; Arabidopsis thaliana; Article; auxin transport; cell differentiation; cell division; endodermis; meristem; molecular genetics; nonhuman; plant root; plant root cap; priority journal; protein degradation; regulatory mechanism; root development; root growth; root length; root system; shoot; steady state; transcription initiation; zonation; Arabidopsis; cell differentiation; cell division; gene expression regulation; metabolism; physiology; plant root; signal transduction; transport at the cellular level; Arabidopsis; Arabidopsis Proteins; Biological Transport; Cell Differentiation; Cell Division; Cytokinins; Gene Expression Regulation, Plant; Indoleacetic Acids; Meristem; Plant Growth Regulators; Plant Roots; Signal Transduction
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160598
作者单位	Di Mambro, R., Dipartimento di Biologia e Biotecnologie, Laboratory of Functional Genomics and Proteomics of Model Systems, Università di Roma, Sapienza, Rome, 00185, Italy, Dipartimento di Biologia, Università di Pisa, Pisa, 56126, Italy; De Ruvo, M., Dipartimento di Biologia e Biotecnologie, Laboratory of Functional Genomics and Proteomics of Model Systems, Università di Roma, Sapienza, Rome, 00185, Italy, Unit of Chemical-Physics Fundamentals in Chemical Engineering, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, 00128, Italy, Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, United Kingdom; Pacifici, E., Dipartimento di Biologia e Biotecnologie, Laboratory of Functional Genomics and Proteomics of Model Systems, Università di Roma, Sapienza, Rome, 00185, Italy; Salvi, E., Dipartimento di Biologia e Biotecnologie, Laboratory of Functional Genomics and Proteomics of Model Systems, Università di Roma, Sapienza, Rome, 00185, Italy; Sozzan...
推荐引用方式 GB/T 7714	Di Mambro R.,De Ruvo M.,Pacifici E.,et al. Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root[J],2017,114(36).
APA	Di Mambro R..,De Ruvo M..,Pacifici E..,Salvi E..,Sozzani R..,...&Sabatini S..(2017).Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root.Proceedings of the National Academy of Sciences of the United States of America,114(36).
MLA	Di Mambro R.,et al."Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root".Proceedings of the National Academy of Sciences of the United States of America 114.36(2017).