气候变化领域集成服务门户(CCPortal): Filament rigidity and connectivity tune the deformation modes of active biopolymer networks

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DOI	10.1073/pnas.1708625114
	Filament rigidity and connectivity tune the deformation modes of active biopolymer networks
	Stam S.; Freedman S.L.; Banerjee S.; Weirich K.L.; Dinner A.R.; Gardel M.L.
发表日期	2017
ISSN	0027-8424
起始页码	E10037
结束页码	E10045
卷号	114 期号:47
英文摘要	Molecular motors embedded within collections of actin and microtubule filaments underlie the dynamics of cytoskeletal assemblies. Understanding the physics of such motor-filament materials is critical to developing a physical model of the cytoskeleton and designing biomimetic active materials. Here, we demonstrate through experiments and simulations that the rigidity and connectivity of filaments in active biopolymer networks regulates the anisotropy and the length scale of the underlying deformations, yielding materials with variable contractility. We find that semiflexible filaments can be compressed and bent by motor stresses, yielding materials that undergo predominantly biaxial deformations. By contrast, rigid filament bundles slide without bending under motor stress, yielding materials that undergo predominantly uniaxial deformations. Networks dominated by biaxial deformations are robustly contractile over a wide range of connectivities, while networks dominated by uniaxial deformations can be tuned from extensile to contractile through cross-linking. These results identify physical parameters that control the forces generated within motor-filament arrays and provide insight into the self-organization and mechanics of cytoskeletal assemblies. © 2017, National Academy of Sciences. All rights reserved.
英文关键词	Actin; Active matter; Agent-based simulation; Mechanics; Myosin
语种	英语
scopus关键词	actin; biopolymer; molecular motor; actin; actin binding protein; carrier protein; fascin; filamin; myosin; actin filament; Article; biopolymer structure; compression; connectome; controlled study; cross linking; cytoskeleton; force; molecular mechanics; muscle contractility; physical parameters; polymerization; priority journal; protein assembly; rigidity; simulation; stress; actin filament; animal; biological model; biomechanics; chemistry; chicken; computer simulation; Leporidae; metabolism; microtubule; ultrastructure; Actin Cytoskeleton; Actins; Animals; Biomechanical Phenomena; Carrier Proteins; Chickens; Computer Simulation; Cytoskeleton; Filamins; Microfilament Proteins; Microtubules; Models, Biological; Myosins; Rabbits
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160573
作者单位	Stam, S., Biophysical Sciences Graduate Program, University of Chicago, Chicago, IL 60637, United States, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, United States; Freedman, S.L., James Franck Institute, University of Chicago, Chicago, IL 60637, United States, Department of Physics, University of Chicago, Chicago, IL 60637, United States; Banerjee, S., James Franck Institute, University of Chicago, Chicago, IL 60637, United States, Department of Physics and Astronomy, University College London, London, WC1E 6BT, United Kingdom, Institute for Physics of Living Systems, University College London, London, WC1E 6BT, United Kingdom; Weirich, K.L., James Franck Institute, University of Chicago, Chicago, IL 60637, United States; Dinner, A.R., Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, United States, James Franck Institute, University of Chicago, Chicago, IL 60637, United States, Department of Chemistry, University of Chicago, Chicago, ...
推荐引用方式 GB/T 7714	Stam S.,Freedman S.L.,Banerjee S.,et al. Filament rigidity and connectivity tune the deformation modes of active biopolymer networks[J],2017,114(47).
APA	Stam S.,Freedman S.L.,Banerjee S.,Weirich K.L.,Dinner A.R.,&Gardel M.L..(2017).Filament rigidity and connectivity tune the deformation modes of active biopolymer networks.Proceedings of the National Academy of Sciences of the United States of America,114(47).
MLA	Stam S.,et al."Filament rigidity and connectivity tune the deformation modes of active biopolymer networks".Proceedings of the National Academy of Sciences of the United States of America 114.47(2017).