气候变化领域集成服务门户(CCPortal): A comprehensive genomic history of extinct and living elephants

CCPortal

DOI	10.1073/pnas.1720554115
	A comprehensive genomic history of extinct and living elephants
	Palkopoulou E.; Lipson M.; Mallick S.; Nielsen S.; Rohland N.; Baleka S.; Karpinski E.; Ivancevic A.M.; To T.-H.; Daniel Kortschak R.; Raison J.M.; Qu Z.; Chin T.-J.; Alt K.W.; Claesson S.; Dalén L.; MacPhee R.D.E.; Meller H.; Roca A.L.; Ryder O.A.; Heiman D.; Young S.; Breen M.; Williams C.; Aken B.L.; Ruffier M.; Karlsson E.; Johnson J.; Palma F.D.; Alfoldi J.; Adelson D.L.; Mailund T.; Munch K.; Lindblad-Toh K.; Hofreiter M.; Poinar H.; Reich D.
发表日期	2018
ISSN	0027-8424
起始页码	E2566
结束页码	E2574
卷号	115 期号:11
英文摘要	Elephantids are the world’s most iconic megafaunal family, yet there is no comprehensive genomic assessment of their relationships. We report a total of 14 genomes, including 2 from the American mastodon, which is an extinct elephantid relative, and 12 spanning all three extant and three extinct elephantid species including an ∼120,000-y-old straight-tusked elephant, a Columbian mammoth, and woolly mammoths. Earlier genetic studies modeled elephantid evolution via simple bifurcating trees, but here we show that interspecies hybridization has been a recurrent feature of elephantid evolution. We found that the genetic makeup of the straight-tusked elephant, previously placed as a sister group to African forest elephants based on lower coverage data, in fact comprises three major components. Most of the straight-tusked elephant’s ancestry derives from a lineage related to the ancestor of African elephants while its remaining ancestry consists of a large contribution from a lineage related to forest elephants and another related to mammoths. Columbian and woolly mammoths also showed evidence of interbreeding, likely following a latitudinal cline across North America. While hybridization events have shaped elephantid history in profound ways, isolation also appears to have played an important role. Our data reveal nearly complete isolation between the ancestors of the African forest and savanna elephants for ∼500,000 y, providing compelling justification for the conservation of forest and savanna elephants as separate species. © 2018 National Academy of Sciences. All Rights Reserved.
英文关键词	Admixture; Elephantid evolution; Mammoth; Paleogenomics; Species divergence
语种	英语
scopus关键词	Article; elephant; evolution; extinct species; gene flow; genomics; heredity; interbreeding; interspecific hybridization; Loxodonta africana; Loxodonta cyclotis; Mammuthus columbi; mastodon; nonhuman; Palaeoloxodon antiquus; phylogeny; population size; population structure; priority journal; species diversity; woolly mammoth; animal; classification; elephant; fossil; genetics; genome; genomics; history; mammoth; molecular evolution; species extinction; Animals; Elephants; Evolution, Molecular; Extinction, Biological; Fossils; Gene Flow; Genome; Genomics; History, Ancient; Mammoths; Mastodons; Phylogeny
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160553
作者单位	Palkopoulou, E., Department of Genetics, Harvard Medical School, Boston, MA 02115, United States, Broad Institute of MIT and Harvard, Cambridge, MA 02142, United States; Lipson, M., Department of Genetics, Harvard Medical School, Boston, MA 02115, United States; Mallick, S., Department of Genetics, Harvard Medical School, Boston, MA 02115, United States, Broad Institute of MIT and Harvard, Cambridge, MA 02142, United States; Nielsen, S., Bioinformatics Research Centre, Aarhus University, Aarhus, DK-8000, Denmark; Rohland, N., Department of Genetics, Harvard Medical School, Boston, MA 02115, United States; Baleka, S., Unit of General Zoology–Evolutionary Adaptive Genomics, Institute of Biochemistry and Biology, Faculty of Mathematics and Life Sciences, University of Potsdam, Potsdam, 14476, Germany; Karpinski, E., McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, Hamilton, ON L8S 4L9, Canada, Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada, Depar...
推荐引用方式 GB/T 7714	Palkopoulou E.,Lipson M.,Mallick S.,et al. A comprehensive genomic history of extinct and living elephants[J],2018,115(11).
APA	Palkopoulou E..,Lipson M..,Mallick S..,Nielsen S..,Rohland N..,...&Reich D..(2018).A comprehensive genomic history of extinct and living elephants.Proceedings of the National Academy of Sciences of the United States of America,115(11).
MLA	Palkopoulou E.,et al."A comprehensive genomic history of extinct and living elephants".Proceedings of the National Academy of Sciences of the United States of America 115.11(2018).