气候变化领域集成服务门户(CCPortal): Roles for ClpXP in regulating the circadian clock in Synechococcus elongatus

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DOI	10.1073/pnas.1800828115
	Roles for ClpXP in regulating the circadian clock in Synechococcus elongatus
	Cohen S.E.; McKnight B.M.; Golden S.S.
发表日期	2018
ISSN	0027-8424
起始页码	E7805
结束页码	E7813
卷号	115 期号:33
英文摘要	In cyanobacteria, the KaiABC posttranslational oscillator drives circadian rhythms of gene expression and controls the timing of cell division. The Kai-based oscillator can be reconstituted in vitro, demonstrating that the clock can run without protein synthesis and degradation; however, protein degradation is known to be important for clock function in vivo. Here, we report that strains deficient in the ClpXP1P2 protease have, in addition to known long-period circadian rhythms, an exaggerated ability to synchronize with the external environment (reduced “jetlag”) compared with WT strains. Deletion of the ClpX chaperone, but not the protease subunits ClpP1 or ClpP2, results in cell division defects in a manner that is dependent on the expression of a dusk-peaking factor. We propose that chaperone activities of ClpX are required to coordinate clock control of cell division whereas the protease activities of the ClpXP1P2 complex are required to maintain appropriate periodicity of the clock and its synchronization with the external environment. © 2018 National Academy of Sciences. All rights reserved.
英文关键词	Cell division; Circadian rhythms; ClpXP protease; Cyanobacteria
语种	英语
scopus关键词	bacterial protein; chaperone; protein ClpXP; proteinase; unclassified drug; bacterial protein; chaperone; endopeptidase Clp; Article; cell cycle regulation; cell division; circadian rhythm; complex formation; controlled study; enzyme activity; enzyme regulation; nonhuman; priority journal; protein depletion; protein function; Synechococcus elongatus; circadian rhythm; enzymology; genetics; metabolism; physiology; protein unfolding; Synechococcus; Bacterial Proteins; Circadian Rhythm; Endopeptidase Clp; Molecular Chaperones; Protein Unfolding; Synechococcus
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160481
作者单位	Cohen, S.E., Center for Circadian Biology, Division of Biological Sciences, University of California, San Diego, CA 92093, United States, Department of Biological Sciences, California State University, Los Angeles, CA 90032, United States; McKnight, B.M., Center for Circadian Biology, Division of Biological Sciences, University of California, San Diego, CA 92093, United States; Golden, S.S., Center for Circadian Biology, Division of Biological Sciences, University of California, San Diego, CA 92093, United States
推荐引用方式 GB/T 7714	Cohen S.E.,McKnight B.M.,Golden S.S.. Roles for ClpXP in regulating the circadian clock in Synechococcus elongatus[J],2018,115(33).
APA	Cohen S.E.,McKnight B.M.,&Golden S.S..(2018).Roles for ClpXP in regulating the circadian clock in Synechococcus elongatus.Proceedings of the National Academy of Sciences of the United States of America,115(33).
MLA	Cohen S.E.,et al."Roles for ClpXP in regulating the circadian clock in Synechococcus elongatus".Proceedings of the National Academy of Sciences of the United States of America 115.33(2018).