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DOI	10.1073/pnas.2001384117
	Establishing rod shape from spherical; peptidoglycan-deficient bacterial spores
	Zhang H.; Mulholland G.A.; Seef S.; Zhu S.; Zhu S.; Liu J.; Liu J.; Mignot T.; Nan B.
发表日期	2020
ISSN	0027-8424
起始页码	14444
结束页码	14452
卷号	117 期号:25
英文摘要	Chemical-induced spores of the Gram-negative bacterium Myxococcus xanthus are peptidoglycan (PG)-deficient. It is unclear how these spherical spores germinate into rod-shaped, walled cells without preexisting PG templates. We found that germinating spores first synthesize PG randomly on spherical surfaces. MglB, a GTPase-activating protein, forms a cluster that responds to the status of PG growth and stabilizes at one future cell pole. Following MglB, the Ras family GTPase MglA localizes to the second pole. MglA directs molecular motors to transport the bacterial actin homolog MreB and the Rod PG synthesis complexes away from poles. The Rod system establishes rod shape de novo by elongating PG at nonpolar regions. Thus, similar to eukaryotic cells, the interactions between GTPase, cytoskeletons, and molecular motors initiate spontaneous polarization in bacteria. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	Germination; Gliding motor; GTPase; MreB; Rod system
语种	英语
scopus关键词	actin; guanosine triphosphatase; membrane protein; molecular motor; MreB protein; peptidoglycan; Rod protein; unclassified drug; bacterial protein; guanosine triphosphatase activating protein; MglA protein, Myxococcus xanthus; peptidoglycan; Article; bacterial spore; bacterial structures; cell interaction; cytoskeleton; eukaryotic cell; Myxococcus xanthus; nonhuman; polar body; polarization; priority journal; protein degradation; protein function; protein localization; protein protein interaction; protein stability; protein synthesis; spore germination; surface property; translation elongation; bacterial spore; cell polarity; cell wall; cytology; electron microscopy; genetics; growth, development and aging; metabolism; morphogenesis; ultrastructure; Bacterial Proteins; Cell Polarity; Cell Wall; GTPase-Activating Proteins; Microscopy, Electron; Morphogenesis; Myxococcus xanthus; Peptidoglycan; Spores, Bacterial
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160281
作者单位	Zhang, H., Department of Biology, Texas A&M University, College Station, TX 77843, United States; Mulholland, G.A., Department of Biology, Texas A&M University, College Station, TX 77843, United States; Seef, S., Laboratoire de Chimie Bactérienne, CNRS-Université Aix Marseille UMR7283, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Zhu, S., Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, United States; Zhu, S., Microbial Sciences Institute, Yale University, West Haven, CT 06516, United States; Liu, J., Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, United States; Liu, J., Microbial Sciences Institute, Yale University, West Haven, CT 06516, United States; Mignot, T., Laboratoire de Chimie Bactérienne, CNRS-Université Aix Marseille UMR7283, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Nan, B., Department of Biology, Texas A&M University, College Station, TX...
推荐引用方式 GB/T 7714	Zhang H.,Mulholland G.A.,Seef S.,et al. Establishing rod shape from spherical; peptidoglycan-deficient bacterial spores[J],2020,117(25).
APA	Zhang H..,Mulholland G.A..,Seef S..,Zhu S..,Zhu S..,...&Nan B..(2020).Establishing rod shape from spherical; peptidoglycan-deficient bacterial spores.Proceedings of the National Academy of Sciences of the United States of America,117(25).
MLA	Zhang H.,et al."Establishing rod shape from spherical; peptidoglycan-deficient bacterial spores".Proceedings of the National Academy of Sciences of the United States of America 117.25(2020).