气候变化领域集成服务门户(CCPortal): EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology in Drosophila

CCPortal

DOI	10.1073/pnas.2004262117
	EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology in Drosophila
	Abrieux A.; Xue Y.; Cai Y.; Lewald K.M.; Nguyen H.N.; Zhang Y.; Chiu J.C.
发表日期	2020
ISSN	0027-8424
起始页码	15293
结束页码	15304
卷号	117 期号:26
英文摘要	Organisms possess photoperiodic timing mechanisms to detect variations in day length and temperature as the seasons progress. The nature of the molecular mechanisms interpreting and signaling these environmental changes to elicit downstream neuroendocrine and physiological responses are just starting to emerge. Here, we demonstrate that, in Drosophila melanogaster, EYES ABSENT (EYA) acts as a seasonal sensor by interpreting photoperiodic and temperature changes to trigger appropriate physiological responses. We observed that tissue-specific genetic manipulation of eya expression is sufficient to disrupt the ability of flies to sense seasonal cues, thereby altering the extent of female reproductive dormancy. Specifically, we observed that EYA proteins, which peak at night in short photoperiod and accumulate at higher levels in the cold, promote reproductive dormancy in female D. melanogaster. Furthermore, we provide evidence indicating that the role of EYA in photoperiodism and temperature sensing is aided by the stabilizing action of the light-sensitive circadian clock protein TIMELESS (TIM). We postulate that increased stability and level of TIM at night under short photoperiod together with the production of cold-induced and light-insensitive TIM isoforms facilitate EYA accumulation in winter conditions. This is supported by our observations that tim null mutants exhibit reduced incidence of reproductive dormancy in simulated winter conditions, while flies overexpressing tim show an increased incidence of reproductive dormancy even in long photoperiod. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	Alternative Splicing; Circadian Clock; photoperiod; Seasonality; Temperature
语种	英语
scopus关键词	isoprotein; protein EYA; protein timeless; transcription factor CLOCK; unclassified drug; Drosophila protein; eya protein, Drosophila; eye protein; tim protein, Drosophila; adult; animal experiment; Article; circadian rhythm; cold sensation; controlled study; Diptera; dormancy; Drosophila melanogaster; female; female genital system; genetic manipulation; light; night; nonhuman; photoperiodicity; priority journal; protein expression; protein stability; protein synthesis; seasonal variation; temperature sense; tissue specificity; winter; animal; Drosophila melanogaster; gene expression regulation; genetics; metabolism; physiology; reproduction; season; temperature; Animals; Drosophila melanogaster; Drosophila Proteins; Eye Proteins; Gene Expression Regulation; Photoperiod; Reproduction; Seasons; Temperature
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160277
作者单位	Abrieux, A., Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, United States; Xue, Y., Department of Biology, University of Nevada Reno, Reno, NV 89557, United States; Cai, Y., Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, United States; Lewald, K.M., Department of Biology, University of Nevada Reno, Reno, NV 89557, United States; Nguyen, H.N., Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, United States; Zhang, Y., Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, United States; Chiu, J.C., Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, United States
推荐引用方式 GB/T 7714	Abrieux A.,Xue Y.,Cai Y.,et al. EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology in Drosophila[J],2020,117(26).
APA	Abrieux A..,Xue Y..,Cai Y..,Lewald K.M..,Nguyen H.N..,...&Chiu J.C..(2020).EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology in Drosophila.Proceedings of the National Academy of Sciences of the United States of America,117(26).
MLA	Abrieux A.,et al."EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology in Drosophila".Proceedings of the National Academy of Sciences of the United States of America 117.26(2020).