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| DOI | 10.1073/pnas.2011785117 |
| Stick-slip model for actin-driven cell protrusions; cell polarization; and crawling | |
| Sens P. | |
| 发表日期 | 2020 |
| ISSN | 0027-8424 |
| 起始页码 | 24670 |
| 结束页码 | 24678 |
| 卷号 | 117期号:40 |
| 英文摘要 | Cell crawling requires the generation of intracellular forces by the cytoskeleton and their transmission to an extracellular substrate through specific adhesion molecules. Crawling cells show many features of excitable systems, such as spontaneous symmetry breaking and crawling in the absence of external cues, and periodic and propagating waves of activity. Mechanical instabilities in the active cytoskeleton network and feedback loops in the biochemical network of activators and repressors of cytoskeleton dynamics have been invoked to explain these dynamical features. Here, I show that the interplay between the dynamics of cell-substrate adhesion and linear cellular mechanics is sufficient to reproduce many nonlinear dynamical patterns observed in spreading and crawling cells. Using an analytical formalism of the molecular clutch model of cell adhesion, regulated by local mechanical forces, I show that cellular traction forces exhibit stick-slip dynamics resulting in periodic waves of protrusion/ retraction and propagating waves along the cell edge. This can explain spontaneous symmetry breaking and polarization of spreading cells, leading to steady crawling or bipedal motion, and bistability, where persistent cell motion requires a sufficiently strong transient external stimulus. The model also highlights the role of membrane tension in providing the long-range mechanical communication across the cell required for symmetry breaking. © 2020 National Academy of Sciences. All rights reserved. |
| 英文关键词 | Cell motility; Membrane tension; Stick-slip; Symmetry breaking |
| 语种 | 英语 |
| scopus关键词 | actin; biological model; biomechanics; cell adhesion; cell motion; cell polarity; cell surface; cells; chemistry; cytology; cytoskeleton; kinetics; metabolism; Actins; Biomechanical Phenomena; Cell Adhesion; Cell Movement; Cell Polarity; Cell Surface Extensions; Cells; Cytoskeleton; Kinetics; Models, Biological |
| 来源期刊 | Proceedings of the National Academy of Sciences of the United States of America
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| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/160216 |
| 作者单位 | Sens, P., Laboratoire Physico-Chimie Curie, Institut Curie, Centre de Recherche, Paris Sciences et Lettres Research University, Centre National de la Recherche Scientifique, Paris, 75005, France, Université Pierre et Marie Curie, Sorbonne Universités, Paris, 75248, France |
| 推荐引用方式 GB/T 7714 | Sens P.. Stick-slip model for actin-driven cell protrusions; cell polarization; and crawling[J],2020,117(40). |
| APA | Sens P..(2020).Stick-slip model for actin-driven cell protrusions; cell polarization; and crawling.Proceedings of the National Academy of Sciences of the United States of America,117(40). |
| MLA | Sens P.."Stick-slip model for actin-driven cell protrusions; cell polarization; and crawling".Proceedings of the National Academy of Sciences of the United States of America 117.40(2020). |
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