气候变化领域集成服务门户(CCPortal): The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus

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DOI	10.1073/pnas.2002783117
	The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus
	Mercier R.; Bautista S.; Delannoy M.; Gibert M.; Guiseppi A.; Herrou J.; Mauriello E.M.F.; Mignot T.
发表日期	2020
ISSN	0027-8424
起始页码	28366
结束页码	28373
卷号	117 期号:45
英文摘要	Type IV pili (Tfp) are highly conserved macromolecular structures that fulfill diverse cellular functions, such as adhesion to host cells, the import of extracellular DNA, kin recognition, and cell motility (twitching). Outstandingly, twitching motility enables a poorly understood process by which highly coordinated groups of hundreds of cells move in cooperative manner, providing a basis for multicellular behaviors, such as biofilm formation. In the social bacteria Myxococcus xanthus, we know that twitching motility is under the dependence of the small GTPase MglA, but the underlying molecular mechanisms remain elusive. Here we show that MglA complexed to GTP recruits a newly characterized Tfp regulator, termed SgmX, to activate Tfp machines at the bacterial cell pole. This mechanism also ensures spatial regulation of Tfp, explaining how MglA switching provokes directional reversals. This discovery paves the way to elucidate how polar Tfp machines are regulated to coordinate multicellular movements, a conserved feature in twitching bacteria. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	Type IV pilus \| cell motility \| small GTPase \| Myxococcus xanthus
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/160200
作者单位	Mercier, R., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Bautista, S., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Delannoy, M., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Gibert, M., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Guiseppi, A., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Herrou, J., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Mauriello, E.M.F., Aix-Marseille Université-CNRS (UMR...
推荐引用方式 GB/T 7714	Mercier R.,Bautista S.,Delannoy M.,et al. The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus[J],2020,117(45).
APA	Mercier R..,Bautista S..,Delannoy M..,Gibert M..,Guiseppi A..,...&Mignot T..(2020).The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus.Proceedings of the National Academy of Sciences of the United States of America,117(45).
MLA	Mercier R.,et al."The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus".Proceedings of the National Academy of Sciences of the United States of America 117.45(2020).