气候变化领域集成服务门户(CCPortal): Detection and formation scenario of citric acid; pyruvic acid; and other possible metabolism precursors in carbonaceous meteorites

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DOI	10.1073/pnas.1105715108
	Detection and formation scenario of citric acid; pyruvic acid; and other possible metabolism precursors in carbonaceous meteorites
	Cooper G.; Reed C.; Nguyen D.; Carter M.; Wang Y.
发表日期	2011
ISSN	0027-8424
起始页码	14015
结束页码	14020
卷号	108 期号:34
英文摘要	Carbonaceous meteorites deliver a variety of organic compounds to Earth that may have played a role in the origin and/or evolution of biochemical pathways. Some apparently ancient and critical metabolic processes require several compounds, some of which are relatively labile such as keto acids. Therefore, a prebiotic setting for any such individual process would have required either a continuous distant source for the entire suite of intact precursor molecules and/or an energetic and compact local synthesis, particularly of the more fragile members. To date, compounds such as pyruvic acid, oxaloacetic acid, citric acid, isocitric acid, and α-ketoglutaric acid (all members of the citric acid cycle) have not been identified in extraterrestrial sources or, as a group, as part of a "one pot" suite of compounds synthesized under plausibly prebiotic conditions. We have identified these compounds and others in carbonaceous meteorites and/or as low temperature (laboratory) reaction products of pyruvic acid. In meteorites, we observe many as part of three newly reported classes of compounds: keto acids (pyruvic acid and homologs), hydroxy tricarboxylic acids (citric acid and homologs), and tricarboxylic acids. Laboratory syntheses using 13C-labeled reactants demonstrate that one compound alone, pyruvic acid, can produce several (nonenzymatic) members of the citric acid cycle including oxaloacetic acid. The isotopic composition of some of the meteoritic keto acids points to interstellar or presolar origins, indicating that such compounds might also exist in other planetary systems.
英文关键词	Alan Hills; Citrate; Interstellar nitriles; Murchison meteorite; Pyruvate
语种	英语
scopus关键词	2 oxoglutaric acid; citric acid; fumaric acid; isocitric acid; ketene derivative; levulinic acid; maleic acid; nitrile; oxaloacetic acid; oxoacid; prebiotic agent; pyruvic acid; succinic acid; tricarboxylic acid; water; article; astronomy; ion pair chromatography; mass fragmentography; mass spectrometry; metabolism; molecular weight; priority journal; Biogenesis; Carbon; Citric Acid; Evolution, Chemical; Extraterrestrial Environment; Mass Spectrometry; Meteoroids; Oxaloacetic Acids; Pyruvic Acid; Reference Standards; Stars, Celestial
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/159000
作者单位	Cooper, G., Exobiology Branch, Space Science Division, National Aeronautics and Space Administration-Ames Research Center, Moffett Field, CA 94035, United States; Reed, C., Exobiology Branch, Space Science Division, National Aeronautics and Space Administration-Ames Research Center, Moffett Field, CA 94035, United States; Nguyen, D., Exobiology Branch, Space Science Division, National Aeronautics and Space Administration-Ames Research Center, Moffett Field, CA 94035, United States; Carter, M., Exobiology Branch, Space Science Division, National Aeronautics and Space Administration-Ames Research Center, Moffett Field, CA 94035, United States; Wang, Y., Development, Planning, Research, and Analysis/ZymaX Forensics Isotope, 600 South Andreasen Drive, Escondido, CA 92029, United States
推荐引用方式 GB/T 7714	Cooper G.,Reed C.,Nguyen D.,et al. Detection and formation scenario of citric acid; pyruvic acid; and other possible metabolism precursors in carbonaceous meteorites[J],2011,108(34).
APA	Cooper G.,Reed C.,Nguyen D.,Carter M.,&Wang Y..(2011).Detection and formation scenario of citric acid; pyruvic acid; and other possible metabolism precursors in carbonaceous meteorites.Proceedings of the National Academy of Sciences of the United States of America,108(34).
MLA	Cooper G.,et al."Detection and formation scenario of citric acid; pyruvic acid; and other possible metabolism precursors in carbonaceous meteorites".Proceedings of the National Academy of Sciences of the United States of America 108.34(2011).