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DOI	10.1073/pnas.1422225112
	Meteorite-catalyzed syntheses of nucleosides and of other prebiotic compounds from formamide under proton irradiation
	Saladino R.; Carota E.; Botta G.; Kapralov M.; Timoshenko G.N.; Rozanov A.Y.; Krasavin E.; Di Mauro E.
发表日期	2015
ISSN	0027-8424
起始页码	E2746
结束页码	E2755
卷号	112 期号:21
英文摘要	Liquid formamide has been irradiated by high-energy proton beams in the presence of powdered meteorites, and the products of the catalyzed resulting syntheses were analyzed by mass spectrometry. Relative to the controls (no radiation, or no formamide, or no catalyst), an extremely rich, variegate, and prebiotically relevant panel of compounds was observed. The meteorites tested were representative of the four major classes: iron, stony iron, chondrites, and achondrites. The products obtained were amino acids, carboxylic acids, nucleobases, sugars, and, most notably, four nucleosides: cytidine, uridine, adenosine, and thymidine. In accordance with theoretical studies, the detection of HCN oligomers suggests the occurrence of mechanisms based on the generation of radical cyanide species (CN·) for the synthesis of nucleobases. Given that many of the compounds obtained are key components of extant organisms, these observations contribute to outline plausible exogenous high-energy-based prebiotic scenarios and their. © 2015, National Academy of Sciences. All rights reserved.
英文关键词	Formamide; Meteorites; Nucleosides; Origin of life; Prebiotic syntheses
语种	英语
scopus关键词	acid; adenosine; amino acid; carbohydrate; carboxylic acid; cyanide; cytidine; formamide; iron; nucleic acid base; nucleoside; oligomer; prebiotic agent; thymidine; uridine; formamide; formamide derivative; nucleoside; proton; Article; astronomy; catalysis; extant species; priority journal; proton radiation; theoretical study; biogenesis; chemical model; chemical structure; chemistry; radiation response; synthesis; Amino Acids; Carboxylic Acids; Catalysis; Evolution, Chemical; Formamides; Meteoroids; Models, Chemical; Molecular Structure; Nucleosides; Origin of Life; Protons
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/158982
作者单位	Saladino, R., Dipartimento di Scienze Ecologiche E Biologiche, Università Della Tuscia, Viterbo, 01100, Italy; Carota, E., Dipartimento di Scienze Ecologiche E Biologiche, Università Della Tuscia, Viterbo, 01100, Italy; Botta, G., Dipartimento di Scienze Ecologiche E Biologiche, Università Della Tuscia, Viterbo, 01100, Italy; Kapralov, M., Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, 141980, Russian Federation; Timoshenko, G.N., Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, 141980, Russian Federation; Rozanov, A.Y., Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, 141980, Russian Federation; Krasavin, E., Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, 141980, Russian Federation; Di Mauro, E., Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Biologia E Biotecnologie Charles Darwin, Sapienza-Università di Roma, Rome, 00185, Italy
推荐引用方式 GB/T 7714	Saladino R.,Carota E.,Botta G.,et al. Meteorite-catalyzed syntheses of nucleosides and of other prebiotic compounds from formamide under proton irradiation[J],2015,112(21).
APA	Saladino R..,Carota E..,Botta G..,Kapralov M..,Timoshenko G.N..,...&Di Mauro E..(2015).Meteorite-catalyzed syntheses of nucleosides and of other prebiotic compounds from formamide under proton irradiation.Proceedings of the National Academy of Sciences of the United States of America,112(21).
MLA	Saladino R.,et al."Meteorite-catalyzed syntheses of nucleosides and of other prebiotic compounds from formamide under proton irradiation".Proceedings of the National Academy of Sciences of the United States of America 112.21(2015).