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| DOI | 10.1016/j.cbpa.2020.110865 |
| Phenotypic plasticity; genetic assimilation; and genetic compensation in hypoxia adaptation of high-altitude vertebrates | |
| Storz J.F.; Scott G.R. | |
| 发表日期 | 2021 |
| ISSN | 10956433 |
| 卷号 | 253 |
| 英文摘要 | Important questions about mechanisms of physiological adaptation concern the role of phenotypic plasticity and the extent to which acclimatization responses align with genetic responses to selection. Such questions can be addressed in experimental studies of high-altitude vertebrates by investigating how mechanisms of acclimatization to hypoxia in lowland natives may influence genetic adaptation to hypoxia in highland natives. Evidence from high-altitude mammals suggest that evolved changes in some physiological traits involved canalization of the ancestral acclimatization response to hypoxia (genetic assimilation), a mechanism that results in an evolved reduction in plasticity. In addition to cases where adaptive plasticity may have facilitated genetic adaptation, evidence also suggests that some physiological changes in high-altitude natives are the result of selection to mitigate maladaptive plastic responses to hypoxia (genetic compensation). Examples of genetic compensation involve the attenuation of hypoxic pulmonary hypertension in Tibetan humans and other mammals native to high altitude. Here we discuss examples of adaptive physiological phenotypes in high-altitude natives that may have evolved by means of genetic assimilation or genetic compensation. © 2020 |
| 语种 | 英语 |
| scopus关键词 | Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/158275 |
| 作者单位 | School of Biological Sciences; University of Nebraska; Lincoln; NE; United States; Department of Biology; McMaster University; Hamilton; ON; Canada |
| 推荐引用方式 GB/T 7714 | Storz J.F.,Scott G.R.. Phenotypic plasticity; genetic assimilation; and genetic compensation in hypoxia adaptation of high-altitude vertebrates[J],2021,253. |
| APA | Storz J.F.,&Scott G.R..(2021).Phenotypic plasticity; genetic assimilation; and genetic compensation in hypoxia adaptation of high-altitude vertebrates.,253. |
| MLA | Storz J.F.,et al."Phenotypic plasticity; genetic assimilation; and genetic compensation in hypoxia adaptation of high-altitude vertebrates".253(2021). |
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