气候变化领域集成服务门户(CCPortal): Aquatic risks from human pharmaceuticals - Modelling temporal trends of carbamazepine and ciprofloxacin at the global scale

CCPortal

DOI	10.1088/1748-9326/ab0071
	Aquatic risks from human pharmaceuticals - Modelling temporal trends of carbamazepine and ciprofloxacin at the global scale
	Oldenkamp R.; Beusen A.H.W.; Huijbregts M.A.J.
发表日期	2019
ISSN	17489318
卷号	14 期号:3
英文摘要	Despite the worldwide presence of pharmaceuticals in the aquatic environment, a comprehensive picture of their aquatic risk (AR) at the global scale has not yet been produced. Here, we present a procedure to estimate ARs of human pharmaceuticals at a freshwater ecoregion level. First, we predicted country- and year-specific per capita consumption with a regression model. Second, we calculated spatially explicit freshwater concentrations via a combination of mass balance models, addressing the pharmaceutical's fate in respectively humans, wastewater treatment plants and the environment. Finally, we divided the freshwater concentrations at the level of individual freshwater ecoregions with the regulatory limit value derived from toxicity tests to come to an ecoregion-specific AR. We applied our procedure to model time-trends (1995-2015) of ARs of carbamazepine and ciprofloxacin, two widely detected and regulatory relevant human use pharmaceuticals. Our analysis of carbamazepine and ciprofloxacin showed that ARs, due to exposure to these human pharmaceuticals, typically increased 10-20 fold over the last 20 years. Risks due to carbamazepine exposure were still typically low for the time period assessed (AR < 0.1), although some more densely populated and/or arid ecoregions showed higher ARs (up to 1.1). Risks for ciprofloxacin were found to be much higher with ARs larger than 1 for 223 out of 449 freshwater ecoregions in 2015. Comparison with measured concentrations in ten river basins showed that carbamazepine concentrations were predicted well. Concentrations of ciprofloxacin, measured in four river basins, were, however, generally underestimated by our model with one to two orders of magnitude. We conclude that our procedure provides a good starting point to evaluate ARs of a wide range of human pharmaceuticals at the global scale. © 2019 The Author(s). Published by IOP Publishing Ltd.
英文关键词	global; PCRGLOBWB; pharmaceuticals; temporal risk assessment
语种	英语
scopus关键词	Amides; Antibiotics; Drug products; Regression analysis; Wastewater treatment; Water; Watersheds; Aquatic environments; global; Human pharmaceuticals; Orders of magnitude; PCRGLOBWB; Percapita consumption; Spatially explicit; Wastewater treatment plants; Risk assessment; antibiotics; aquatic ecosystem; comparative study; concentration (composition); drug; global change; risk assessment; temporal analysis; trend analysis
来源期刊	Environmental Research Letters
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/154683
作者单位	Department of Environmental Science, Institute for Wetland and Water Research, Radboud University, Nijmegen, Netherlands; Environment Department, University of York, Heslington, York, YO10 5DD, United Kingdom; PBL Netherlands Environmental Assessment Agency, Bilthoven, Netherlands; Department of Earth Sciences - Geochemistry, Faculty of Geosciences, Utrecht University, Utrecht, Netherlands
推荐引用方式 GB/T 7714	Oldenkamp R.,Beusen A.H.W.,Huijbregts M.A.J.. Aquatic risks from human pharmaceuticals - Modelling temporal trends of carbamazepine and ciprofloxacin at the global scale[J],2019,14(3).
APA	Oldenkamp R.,Beusen A.H.W.,&Huijbregts M.A.J..(2019).Aquatic risks from human pharmaceuticals - Modelling temporal trends of carbamazepine and ciprofloxacin at the global scale.Environmental Research Letters,14(3).
MLA	Oldenkamp R.,et al."Aquatic risks from human pharmaceuticals - Modelling temporal trends of carbamazepine and ciprofloxacin at the global scale".Environmental Research Letters 14.3(2019).