气候变化领域集成服务门户(CCPortal): Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia

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DOI	10.1016/j.marpolbul.2018.11.063
	Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia
	Huo D.; Sun L.; Zhang L.; Ru X.; Liu S.; Yang H.
发表日期	2019
ISSN	0025326X
起始页码	407
结束页码	420
卷号	138
英文摘要	Economically important marine organisms face severe environmental challenges, such as high temperature and low dissolved oxygen, from global climate change. Adverse environmental factors impact the survival and growth of economically important marine organisms, thereby negatively influencing the aquaculture industry. However, little is known about the responses of sea cucumbers to combined environmental co-stressors till now. In this study, ultra-performance liquid chromatography (UPLC) was utilized to obtain metabolic profiles of sea cucumbers. Changes in the concentrations of 84, 68, and 417 metabolites related to the responses of sea cucumbers to heat (26 °C), hypoxia (2 mg/L) and the combined stress, respectively, were observed and analyzed. Representative biomarkers were discussed in detail, including deltaline, fusarin C, halichondrin B and rapanone. The concentration of metabolites involved in the regulation of energy metabolism, including amino acid, carbohydrate and lipid metabolism were significantly changed, and the tricarboxylic acid (TCA)-cycle was significantly altered under heat plus hypoxia. We interpreted these changes partly as an adaptation mechanism in response to environmental stress. Based on the decreased accumulation of glutamine, we hypothesized that heat stress is the main factor that interferes with the process of glutamic acid-glutamine metabolism. The present study showed that combined environmental stressors have a more extensive impact on the metabolites of the respiratory tree in sea cucumbers than single stress. These results would facilitate further development of the sea cucumber as an echinoderm model to study mechanisms of response to adverse environments, as well as to help advance knowledge of the adaptation of marine organisms to global climate change. © 2018 Elsevier Ltd
英文关键词	Anoxia; Echinoderm; Metabolomics; Sea cucumber; Thermal; UPLC
语种	英语
scopus关键词	Amino acids; Aquaculture; Biomolecules; Climate models; Dissolved oxygen; Liquid chromatography; Marine biology; Marine industry; Metabolism; Metabolites; Anoxia; Echinoderm; Metabolomics; Sea cucumber; Thermal; UPLC; Climate change; 5,6 dihydrothymine; 9 cis,11 trans octadecadienoate; acroptilin; alisol C; carvedilol; cyclopiazonic acid; diltiazem; drug metabolite; efepristin; epothilone A; ergocalciferol; forskolin; fusarin C; gentamicin; glutathione disulfide; glycopeptide; heptose; herbimycin; K strophanthin gamma; leukotriene D4; lyngbyatoxin; mitragynine; oxaloglutarate; pravastatin; sarin; tirofiban; unclassified drug; unindexed drug; valiolone; vanillic acid; zopolrestat; oxygen; anoxia; biomarker; echinoderm; environmental factor; environmental stress; hypoxia; metabolism; temperature effect; adaptation; amino acid metabolism; animal tissue; Apostichopus japonicus; Article; carbohydrate metabolism; citric acid cycle; concentration (parameters); controlled study; energy metabolism; environmental stress; heat stress; hypoxia; lipid metabolism; metabolome; metabolomics; nonhuman; nucleotide metabolism; ultra performance liquid chromatography; vitamin metabolism; animal; environment; heat; metabolism; physiology; Stichopus; Apostichopus japonicus; Echinodermata; Holothuroidea; Animals; Environment; Hot Temperature; Metabolome; Metabolomics; Oxygen; Stichopus
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/150199
作者单位	CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China; Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266071, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, 266071, China
推荐引用方式 GB/T 7714	Huo D.,Sun L.,Zhang L.,et al. Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia[J],2019,138.
APA	Huo D.,Sun L.,Zhang L.,Ru X.,Liu S.,&Yang H..(2019).Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia.Marine Pollution Bulletin,138.
MLA	Huo D.,et al."Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia".Marine Pollution Bulletin 138(2019).